Title:
CRYSTALLINE FORM OF BENZOPYRANONE COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2021/060691
Kind Code:
A1
Abstract:
The present invention provides type I crystals, type II crystals, type III crystals, and type IV crystals which are novel crystalline forms of 2-(2,5-difluorophenyl)-3-carboxy-7-chloro-(4H)-4-benzopyranone. In particular, the type IV crystals have excellent physicochemical stability and can be easily used in the preparation of a pharmaceutical composition containing same as an active ingredient.
Inventors:
PARK KYUNG YEON (KR)
Application Number:
PCT/KR2020/010095
Publication Date:
April 01, 2021
Filing Date:
July 30, 2020
Export Citation:
Assignee:
ILAB (KR)
International Classes:
C07D311/30; A61K31/352
Foreign References:
| KR101934651B1 | 2019-01-02 | |||
| KR20080013162A | 2008-02-13 |
Other References:
DONG QIAN; SHEN HONG C.; JIANG MIN: "Efficient synthesis of functionalized chromones via a two-base mediated formal [3+3] cycloaddition", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 57, no. 19, 5 April 2016 (2016-04-05), Amsterdam , NL, pages 2116 - 2120, XP029512947, ISSN: 0040-4039, DOI: 10.1016/j.tetlet.2016.04.010
JIAN-PING LIN, YA-QIU LONG: "Transition metal-free one-pot synthesis of 2-substituted 3-carboxy-4-quinolone and chromone derivatives", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, vol. 49, no. 46, 1 January 2013 (2013-01-01), pages 5313, XP055597047, ISSN: 1359-7345, DOI: 10.1039/c3cc41690a
WILSON BAKER, A. J. FLOYD, J. F. W. MCOMIE, G. POPE, A. S. WEAVING , J. H. WILD: "BAKER, W. et al. Condensation products of phenols and ketones. Part X. The structure of dianin`s compounds, a unique inclusion-forming substance.", JOURNAL OF THE CHEMICAL SOCIETY , 1 January 1956 (1956-01-01), pages 2010 - 2017, XP009526952, ISSN: 0368-1769, DOI: 10.1039/JR9560002010
JIAN-PING LIN, YA-QIU LONG: "Transition metal-free one-pot synthesis of 2-substituted 3-carboxy-4-quinolone and chromone derivatives", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, vol. 49, no. 46, 1 January 2013 (2013-01-01), pages 5313, XP055597047, ISSN: 1359-7345, DOI: 10.1039/c3cc41690a
WILSON BAKER, A. J. FLOYD, J. F. W. MCOMIE, G. POPE, A. S. WEAVING , J. H. WILD: "BAKER, W. et al. Condensation products of phenols and ketones. Part X. The structure of dianin`s compounds, a unique inclusion-forming substance.", JOURNAL OF THE CHEMICAL SOCIETY , 1 January 1956 (1956-01-01), pages 2010 - 2017, XP009526952, ISSN: 0368-1769, DOI: 10.1039/JR9560002010
Attorney, Agent or Firm:
CHOI, Eun Sun (KR)
Download PDF: