Title:
CRYSTALLINE FORM OF BTK KINASE INHIBITOR AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/011316
Kind Code:
A1
Abstract:
The present invention relates to a crystalline form of a BTK kinase inhibitor and a preparation method therefor. In particular, the present invention relates to a type II crystal of (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-(2,6-difluorophenoxy)phenyl)-1,6-dihydro-7H-pyrrolo[2,3-d]pyridazin-7-one (a compound of formula (I)) and a preparation method. The type II crystal of the compound of formula (I) obtained by the present invention has good chemical stability and crystal form stability, and is also better used for clinical treatment as the used crystallization solvent has a low toxicity and low residues.
Inventors:
WU GUAILI (CN)
QIU ZHENJUN (CN)
PAN LIANJIE (CN)
LU YUN (CN)
QIU ZHENJUN (CN)
PAN LIANJIE (CN)
LU YUN (CN)
Application Number:
PCT/CN2018/095573
Publication Date:
January 17, 2019
Filing Date:
July 13, 2018
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
International Classes:
C07D487/04; A61K31/50
Domestic Patent References:
| WO2016007185A1 | 2016-01-14 |
Foreign References:
| CN106939002A | 2017-07-11 |
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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