Title:
CRYSTALLINE FORM OF FREE BASE OF IMIDAZO-ISOINDOLE DERIVATIVE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/001551
Kind Code:
A1
Abstract:
Provided are a crystalline form G of a free base of an imidazo-isoindole derivative and a preparation method therefor. The chemical structure of the compound is shown in formula (I), and the chemical name thereof is (S)-2-(4-(4-(4-(6-fluoro-5H-imidazo[5,1-a] isoindole-5-yl) piperidine-1-yl) phenyl)-1H-pyrazol-1-yl) ethanol. Provided are the application of the crystalline form G of the compound in a pharmaceutical composition and the pharmaceutical use of the crystalline form G and the composition in the preparation of a medicine for treating diseases with pathological characteristics of tryptophan metabolic pathway mediated by IDO (indoleamine-pyrrole-2,3-dioxygenase). The crystalline form G of the compound has good stability, and the crystallization solvent that is used has low toxicity and residue and may be used well in clinical treatment.
Inventors:
CAO XIAOLI (CN)
YOU LINGFENG (CN)
XIAO CHANGQIN (CN)
DU ZHENXING (CN)
WANG LIKUN (CN)
YOU LINGFENG (CN)
XIAO CHANGQIN (CN)
DU ZHENXING (CN)
WANG LIKUN (CN)
Application Number:
PCT/CN2018/093533
Publication Date:
January 03, 2019
Filing Date:
June 29, 2018
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D487/04; A61K31/454; A61P25/00; A61P25/22; A61P25/24; A61P25/28; A61P27/12; A61P31/18; A61P35/00; A61P35/02; A61P35/04; A61P37/06
Domestic Patent References:
| WO2018072742A1 | 2018-04-26 | |||
| WO2016169421A1 | 2016-10-27 |
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
Download PDF: