Title:
CRYSTALLINE FORM OF LEUCOGEN AND METHOD FOR PREPARATION THEREOF AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/124408
Kind Code:
A1
Abstract:
The present invention relates to the field of compound crystal forms, and particularly provides a leucogen crystalline form A, crystalline form B, a method for preparation of the crystalline form B, a pharmaceutical composition, and an application. The crystalline form A and the crystalline form B provided by the present invention have the advantages of good stability, high solubility in water, and good bioavailability.
Inventors:
WU XIUGEN (CN)
LI ZHAOGUANG (CN)
LI HAIDAO (CN)
NIE LIYUN (CN)
LIU YUNFENG (CN)
CAO XU (CN)
WEI FURONG (CN)
LI ZHAOGUANG (CN)
LI HAIDAO (CN)
NIE LIYUN (CN)
LIU YUNFENG (CN)
CAO XU (CN)
WEI FURONG (CN)
Application Number:
PCT/CN2022/125692
Publication Date:
July 06, 2023
Filing Date:
October 17, 2022
Export Citation:
Assignee:
JIANGSU JIBEIER PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D277/06; A61K31/426; A61P7/00; A61P7/06
Foreign References:
| CN103102324A | 2013-05-15 | |||
| CN1810791A | 2006-08-02 | |||
| CN1872844A | 2006-12-06 | |||
| CN1629128A | 2005-06-22 |
Other References:
GANG CHU, LIN HUI,LIU CAI-LIAN,WANG ZHENG-ZE : "Improvement of the Technological Method for the Synthesis of Leucogen", PHARMACEUTICAL AND CLINICAL RESEARCH, 25 August 2012 (2012-08-25), pages 317 - 318, XP093075234, DOI: 10.13664/j.cnki.pcr.2012.04.001
ZHAO LING, YANG BO: "Optimization of Synthetic Process of Leucogen)", 武汉轻工大学学报 (", JOURNAL OF WUHAN POLYTECHNIC UNIVERSITY, vol. 37, no. 4, 1 August 2018 (2018-08-01), pages 104 - 107, XP093075245
ZHAO LING, YANG BO: "Optimization of Synthetic Process of Leucogen)", 武汉轻工大学学报 (", JOURNAL OF WUHAN POLYTECHNIC UNIVERSITY, vol. 37, no. 4, 1 August 2018 (2018-08-01), pages 104 - 107, XP093075245
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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