Title:
Β-CRYSTALLINE FORM OF NAPUTINIB TOSYLATE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2016/101868
Kind Code:
A1
Abstract:
The present invention providesβ-crystalline form of 2 crystalline hydrate of compound N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(ethoxy)-6-quinazolinyl]-4-(dimethylamino)-2-crotonamide tosylate, which has stable form and definite melting point, good chemical stability, resistance to high temperature and light, and is suitable for pharmaceutical use.
Inventors:
TANG TIAN (CN)
XIE SHENGLING (CN)
PENG JIANGHUA (CN)
GAO YUAN (CN)
WANG LILI (CN)
FENG HANLIN (CN)
YU LIN (CN)
XIE SHENGLING (CN)
PENG JIANGHUA (CN)
GAO YUAN (CN)
WANG LILI (CN)
FENG HANLIN (CN)
YU LIN (CN)
Application Number:
PCT/CN2015/098242
Publication Date:
June 30, 2016
Filing Date:
December 22, 2015
Export Citation:
Assignee:
SHENZHEN NEPTUNUS BIOENGINEERING HOLDING CO LTD (CN)
International Classes:
C07D239/94; A61K31/517; A61P35/00; C07C303/32; C07C309/30
Domestic Patent References:
| WO2008053270A2 | 2008-05-08 | |||
| WO2010130758A1 | 2010-11-18 |
Foreign References:
| CN102898386A | 2013-01-30 | |||
| CN104230826A | 2014-12-24 | |||
| CN103965120A | 2014-08-06 |
Attorney, Agent or Firm:
LECOME INTELLETUAL PROPERTY AGNET LTD. (CN)
北京律诚同业知识产权代理有限公司 (CN)
北京律诚同业知识产权代理有限公司 (CN)
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