Title:
CRYSTALLINE FORM A OF REBAUDIOSIDE D, AND PREPARATION METHOD AND APPLICATION THEREFOR
Document Type and Number:
WIPO Patent Application WO/2017/012572
Kind Code:
A1
Abstract:
Provided are crystalline form A of rebaudioside D, and a preparation method and application therefor. In X-ray powder diffraction analysis measured using Cu-Kα rays and with 2θ being expressed in degrees, crystalline form A of rebaudioside D has significant characteristic diffraction peaks at least at 4.53, 6.38, 12.76, 13.52, 17.48, 17.96, 20.07 and 22.63. The preparation method is a suspension method, a solvent evaporation method or a cooling method. The preparation method has a simple process, and is convenient to operate. A rebaudioside D crystalline form A product has a good degree of crystallinity, good water solubility, and high chemical stability.
Inventors:
ZHU LIPING (CN)
MEI XUEFENG (CN)
HUANG YING (CN)
WANG JIANRONG (CN)
ZHANG QI (CN)
MEI XUEFENG (CN)
HUANG YING (CN)
WANG JIANRONG (CN)
ZHANG QI (CN)
Application Number:
PCT/CN2016/090898
Publication Date:
January 26, 2017
Filing Date:
July 21, 2016
Export Citation:
Assignee:
ZHUCHENG HAOTIAN PHARM CO LTD (CN)
International Classes:
C07H15/26; A23L2/02; A23L2/60; A23L19/00; A23L27/30; A23L33/00; A61K31/4402; A61K47/26; A61K47/38; A61P29/00; C07H1/06
Domestic Patent References:
| WO2012082587A2 | 2012-06-21 | |||
| WO2011112892A1 | 2011-09-15 |
Foreign References:
| EP2358730B1 | 2014-01-15 | |||
| CN103709215A | 2014-04-09 | |||
| US20150017284A1 | 2015-01-15 | |||
| CN105037458A | 2015-11-11 |
Other References:
See also references of EP 3327025A4
Attorney, Agent or Firm:
XU & PARTNERS,LLC. (CN)
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