Title:
CRYSTALLINE FORMS OF MESACONINE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/144889
Kind Code:
A1
Abstract:
The present invention relates to crystalline forms of mesaconine. Specifically, the present invention relates to crystalline form A, crystalline form B, and crystalline form C of mesaconine and a preparation method therefor. The method comprises: performing crystallization on mesaconine in a solvent, and performing drying to obtain a target crystalline form. The crystalline forms of mesaconine in the present invention have good solubility, good stability, low hygroscopicity, and good repeatability, and are suitable for long-term storage and drug development.
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Inventors:
GENG YUEFEI (CN)
GENG FUNENG (CN)
MA XIUYING (CN)
CHAO RUOBING (CN)
GENG FUNENG (CN)
MA XIUYING (CN)
CHAO RUOBING (CN)
Application Number:
PCT/CN2019/072874
Publication Date:
August 01, 2019
Filing Date:
January 23, 2019
Export Citation:
Assignee:
GOODDOCTOR PHARMACEUTICAL GROUP (CN)
International Classes:
C07D221/22; A61K31/439; A61P9/04
Foreign References:
| CN102977020A | 2013-03-20 | |||
| CN102146057A | 2011-08-10 | |||
| CN101759640A | 2010-06-30 | |||
| CN102146057A | 2011-08-10 |
Other References:
SAKAI, S. ET AL.: "Partial Synthesis of Isodelphinine and Penduline", YAKUGAKU ZASSHI, vol. 104, no. 7, 25 July 1984 (1984-07-25) - 31 December 1984 (1984-12-31), pages 747 - 748, XP055627143, ISSN: 0031-6903
MORIO, SHIN-ICHI: "Über Mesaconitin, ein zweites neues Aconitum‐Alkaloid. (VI. Mitteilung über Aconitum‐Alkaloide) = Aconitum Alkaloids. VI. Mesaconitine, a Second New Aconitum Alkaloid", JUSTUS LIEBIGS ANNALEN DER CHEMIE, vol. 476, no. 1, 31 December 1929 (1929-12-31), pages 189 - 190, XP009522472, ISSN: 0075-4617, DOI: 10.1002/jlac.19294760108
CHINESE PHARMACOPOEIA, vol. 1, 2015
XIU-XIU LIU ET AL., CHEM. PHARM. BULL, vol. 60, no. 1, 2012, pages 144 - 149
XI-XIAN JIAN ET AL., NAT. PROD. COMMUN, vol. 7, no. 6, 2012, pages 713 - 720
ZHONG-TANG ZHANG ET AL., NAT. PROD. COMMUN, vol. 10, no. 12, 2015, pages 2075 - 2084
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 6792-09-2
"the Chinese Pharmacopoeia", vol. 4, 2015, article "determination method of the melting point"
"Chinese Pharmacopoeia", vol. 4, 2015
See also references of EP 3744712A4
MORIO, SHIN-ICHI: "Über Mesaconitin, ein zweites neues Aconitum‐Alkaloid. (VI. Mitteilung über Aconitum‐Alkaloide) = Aconitum Alkaloids. VI. Mesaconitine, a Second New Aconitum Alkaloid", JUSTUS LIEBIGS ANNALEN DER CHEMIE, vol. 476, no. 1, 31 December 1929 (1929-12-31), pages 189 - 190, XP009522472, ISSN: 0075-4617, DOI: 10.1002/jlac.19294760108
CHINESE PHARMACOPOEIA, vol. 1, 2015
XIU-XIU LIU ET AL., CHEM. PHARM. BULL, vol. 60, no. 1, 2012, pages 144 - 149
XI-XIAN JIAN ET AL., NAT. PROD. COMMUN, vol. 7, no. 6, 2012, pages 713 - 720
ZHONG-TANG ZHANG ET AL., NAT. PROD. COMMUN, vol. 10, no. 12, 2015, pages 2075 - 2084
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 6792-09-2
"the Chinese Pharmacopoeia", vol. 4, 2015, article "determination method of the melting point"
"Chinese Pharmacopoeia", vol. 4, 2015
See also references of EP 3744712A4
Attorney, Agent or Firm:
SINO-CREATIVITY INTELLECTUAL PROPERTY LAW FIRM (CN)
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