CRYSTALLINE FORMS OF SALTS OF FUSED TERA OR PENTA-CYCLIC DIHYDRODIAZEPINOCARAZOLONES, AND USES THEREOF

Title:

CRYSTALLINE FORMS OF SALTS OF FUSED TERA OR PENTA-CYCLIC DIHYDRODIAZEPINOCARAZOLONES, AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2018/157794

Kind Code:

A1

Abstract:

Disclosed herein are salts of (R) -2-fluoro-10a-methyl-7, 8, 9, 10, 10a, 11-hexahydro-5, 6, 7a, 11-tetraazacyclohepta [def] cyclopenta [a] fluoren-4 (5H) -one, and crystalline forms (polymorphs) thereof. Also disclosed herein are methods of preparing those crystalline forms, and methods of using at least one of those crystalline forms in treating a cancer responsive to inhibition of PARP, especially a cancer associated with BRCA1/2 mutant activities or other HR deficiencies, in a subject.

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Inventors:

WANG HEXIANG (CN)
KUANG XIANZHAO (CN)
ZHOU CHANGYOU (US)

Application Number:

PCT/CN2018/077433

Publication Date:

September 07, 2018

Filing Date:

February 27, 2018

Export Citation:

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Assignee:

BEIGENE LTD (KY)
WANG HEXIANG (CN)
KUANG XIANZHAO (CN)
ZHOU CHANGYOU (US)

International Classes:

A61K31/55; C07D487/22; A61P35/00

Domestic Patent References:

WO2017032289A1

2017-03-02

Foreign References:

CN103703004A	2014-04-02
CN106220635A	2016-12-14

Attorney, Agent or Firm:

WU, FENG & ZHANG (CN)

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