Title:
β CRYSTALLINE POLYMORPH OF LEVONORGESTREL, AND MANUFACTURING METHOD FOR SAME
Document Type and Number:
WIPO Patent Application WO/2014/175304
Kind Code:
A1
Abstract:
Provided are a new crystalline form of levonorgestrel, which is useful as an emergency contraception, etc., a manufacturing method for the same, and a drug composition. The powder X-ray diffraction spectrum of this β crystalline polymorph of levonorgestrel has diffraction peaks where the diffraction angle (2θ) is an angle of 2θ=13.9°±0.2°, 14.5°±0.2°, 21.3°±0.2°, 24.9°±0.2°, and 28.2°±0.2°, and has essentially no diffraction peak at the angle 2θ=18.6°±0.2°.
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Inventors:
IWASHITA SHIGEKI (JP)
HAYASHI HIROYUKI (JP)
NAKAGAWA TAKAYOSHI (JP)
MIYAZAKI KOICHI (JP)
HAYASHI HIROYUKI (JP)
NAKAGAWA TAKAYOSHI (JP)
MIYAZAKI KOICHI (JP)
Application Number:
PCT/JP2014/061365
Publication Date:
October 30, 2014
Filing Date:
April 23, 2014
Export Citation:
Assignee:
ASKA PHARM CO LTD (JP)
International Classes:
C07J1/00; A61K31/567; A61P15/18
Domestic Patent References:
| WO2009035527A2 | 2009-03-19 | |||
| WO2012110947A1 | 2012-08-23 |
Other References:
YOKO KAWAGUCHI ET AL.: "Drug and crystal polymorphism", JOURNAL OF HUMAN ENVIRONMENTAL ENGINEERING, vol. 4, no. 2, 2002, pages 310 - 317
QUINKERT,G. ET AL.: "Total Synthesis with a Chirogenic Opening Move Demonstrated on Steroids with Estrane or 18a-Homoestrane Skeleton", HELVETICA CHIMICA ACTA, vol. 78, 1995, pages 1345 - 1391
CRABBE,P. ET AL.: "Long-acting contraceptive agents: x-ray study of levonorgestrel esters", BULLETIN DES SOCIETES CHIMIQUES BELGES, vol. 92, no. 3, 1983, pages 275 - 287
DEANGELIS,N.J. ET AL.: "Crystal and molecular structure of d-norgestrel, a progestational steroid", ACTA CRYSTALLOGRAPHICA, SECTION B: STRUCTURAL CRYSTALLOGRAPHY AND CRYSTAL CHEMISTRY, vol. B31, no. 8, 1975, pages 2040 - 2043
QUINKERT,G. ET AL.: "Total Synthesis with a Chirogenic Opening Move Demonstrated on Steroids with Estrane or 18a-Homoestrane Skeleton", HELVETICA CHIMICA ACTA, vol. 78, 1995, pages 1345 - 1391
CRABBE,P. ET AL.: "Long-acting contraceptive agents: x-ray study of levonorgestrel esters", BULLETIN DES SOCIETES CHIMIQUES BELGES, vol. 92, no. 3, 1983, pages 275 - 287
DEANGELIS,N.J. ET AL.: "Crystal and molecular structure of d-norgestrel, a progestational steroid", ACTA CRYSTALLOGRAPHICA, SECTION B: STRUCTURAL CRYSTALLOGRAPHY AND CRYSTAL CHEMISTRY, vol. B31, no. 8, 1975, pages 2040 - 2043
Attorney, Agent or Firm:
KUWATA Mitsuo (6th Floor Minato Umeda Building, 3-17, Nishitemma 6-chome, Kita-ku, Osaka-sh, Osaka 47, JP)
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