Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
CRYSTALS OF CARBAPENEM DERIVATIVES AND PHARMACEUTICAL PREPARATIONS FOR INJECTION
Document Type and Number:
WIPO Patent Application WO/2000/075143
Kind Code:
A1
Abstract:
Crystals of mono- or tri-hydrates of hydrochlorides of carbapenem compounds useful as antibacterial agents, which are chemically stable and easy to purify; processes for the production of the crystals; and injectable powder preparations manufactured by packing the same. Specifically, crystals of monohydrates of hydrochlorides of carbapenem compounds which have powder X-ray diffraction patterns containing spacings (d) of 5.2, 4.3 and 4.0 Å and crystals of trihydrates of hydrochlorides of carbapenem compounds which have X-ray diffraction patterns containing spacings (d) of 9.0, 4.1 and 2.8 Å; processes for the production of the crystals; and injectable powder preparations manufactured by packing the same.

Inventors:
Chiba, Hiroyuki (Kuresuto Shiho 102 2727-9, Aza Kuboyama Hiraizumi Kamisumachi, Kashima-gun Ibaraki, 314-0146, JP)
Tsujii, Masahiko (1596-5, Omigawa Omigawacho Katori-gun Chiba, 289-0313, JP)
Koiwa, Atsushi (5-9809-159, Doaihoncho Hasakimachi Kashima-gun Ibaraki, 314-0343, JP)
Sakurai, Shin (3061-6, Kasugacho Choshi-shi Chiba, 288-0814, JP)
Kayano, Akio (Century Muramatsu 203 2-7-31, Kamisu Kamisumachi Kashima-gun Ibaraki, 314-0143, JP)
Ishizuka, Hiroyuki (177-35, Miyatsudai Kashima-shi Ibaraki, 314-0006, JP)
Saito, Hiroyuki (Gonoikeohkaryo 125 6-16-27, Shittechuo Kamisumachi Kashima-gun Ibaraki, 314-0112, JP)
Nakamura, Taiju (Guransharionibankan 204 1-10-5, Ohnohara Kamisumachi Kashima-gun Ibaraki, 314-0144, JP)
Kushida, Ikuo (Tsukubanedainiryo 205 9-7, Inarimae Tsukuba-shi Ibaraki, 305-0061, JP)
Suzuki, Yasuyuki (2520-4, Kamiyokoba Tsukuba-shi Ibaraki, 305-0854, JP)
Yoshiba, Takako (3836, Ohsone Tsukuba-shi Ibaraki, 300-3253, JP)
Ashizawa, Kazuhide (410-147, Shimohirooka Tsukuba-shi Ibaraki, 305-0042, JP)
Sakurai, Masahiro (Runbini Umezono 106 2-16-1, Umezono Tsukuba-shi Ibaraki, 305-0045, JP)
Yamamoto, Eiichi (Tsukuba Hills 306 1-11-1, Matsushiro Tsukuba-shi Ibaraki, 305-0035, JP)
Application Number:
PCT/JP2000/003642
Publication Date:
December 14, 2000
Filing Date:
June 05, 2000
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
EISAI CO., LTD. (6-10, Koishikawa 4-chome Bunkyo-ku Tokyo, 112-8088, JP)
Chiba, Hiroyuki (Kuresuto Shiho 102 2727-9, Aza Kuboyama Hiraizumi Kamisumachi, Kashima-gun Ibaraki, 314-0146, JP)
Tsujii, Masahiko (1596-5, Omigawa Omigawacho Katori-gun Chiba, 289-0313, JP)
Koiwa, Atsushi (5-9809-159, Doaihoncho Hasakimachi Kashima-gun Ibaraki, 314-0343, JP)
Sakurai, Shin (3061-6, Kasugacho Choshi-shi Chiba, 288-0814, JP)
Kayano, Akio (Century Muramatsu 203 2-7-31, Kamisu Kamisumachi Kashima-gun Ibaraki, 314-0143, JP)
Ishizuka, Hiroyuki (177-35, Miyatsudai Kashima-shi Ibaraki, 314-0006, JP)
Saito, Hiroyuki (Gonoikeohkaryo 125 6-16-27, Shittechuo Kamisumachi Kashima-gun Ibaraki, 314-0112, JP)
Nakamura, Taiju (Guransharionibankan 204 1-10-5, Ohnohara Kamisumachi Kashima-gun Ibaraki, 314-0144, JP)
Kushida, Ikuo (Tsukubanedainiryo 205 9-7, Inarimae Tsukuba-shi Ibaraki, 305-0061, JP)
Suzuki, Yasuyuki (2520-4, Kamiyokoba Tsukuba-shi Ibaraki, 305-0854, JP)
Yoshiba, Takako (3836, Ohsone Tsukuba-shi Ibaraki, 300-3253, JP)
Ashizawa, Kazuhide (410-147, Shimohirooka Tsukuba-shi Ibaraki, 305-0042, JP)
Sakurai, Masahiro (Runbini Umezono 106 2-16-1, Umezono Tsukuba-shi Ibaraki, 305-0045, JP)
Yamamoto, Eiichi (Tsukuba Hills 306 1-11-1, Matsushiro Tsukuba-shi Ibaraki, 305-0035, JP)
International Classes:
A61K31/407; A61P31/04; C07D477/20; (IPC1-7): C07D477/20; A61K9/14; A61K31/407; A61P31/04
Domestic Patent References:
WO1998052918A1
Foreign References:
EP0773222A1
EP0256377A1
JPH10195076A
JPH10152491A
JPH01268688A
Other References:
LEANZA W.J. ET AL.: 'N-acetimidoyl- and N-formimidoylthienamycin derivatives: Antipseudomonal beta-lactam antibiotics' J. MED. CHEM., vol. 22, no. 12, 1979, pages 1435 - 1436, XP002930747
See also references of EP 1182204A1
Attorney, Agent or Firm:
Furuya, Kaoru (Hamacho-Hanacho Building 6th floor 2-17-8, Nihonbashi-Hamacho Chuo-ku Tokyo, 103-0007, JP)
Download PDF: