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Title:
CRYSTALS OF GLUTATHIONE TRISULFIDE DIHYDRATE AND METHOD OF PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2018/117186
Kind Code:
A1
Abstract:
The present invention relates to a crystals of glutathione trisulfide dihydrate and a method for producing the same. According to the present invention, for example, by concentrating a solution in which glutathione trisulfide is dissolved and then harvesting crystals of the precipitated glutathione trisulfide dihydrate, such crystals can be provided. The present invention also relates to a simple method for producing polysulfide in an aqueous solvent where hydrogen sulfide is not used but thiosulfate is used, the polysulfide being produced by agitating or leaving to stand a solution in which a compound having a thiol group or a disulfide bond and a thiosulfate are dissolved.

Inventors:
FUJIMOTO Akihiro (1-6-1, Otemachi, Chiyoda-k, Tokyo 85, 〒1008185, JP)
NAGANO Hiroshi (1-6-1, Otemachi, Chiyoda-k, Tokyo 85, 〒1008185, JP)
Application Number:
JP2017/045805
Publication Date:
June 28, 2018
Filing Date:
December 20, 2017
Export Citation:
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Assignee:
KYOWA HAKKO BIO CO., LTD. (1-6-1, Otemachi Chiyoda-k, Tokyo 85, 〒1008185, JP)
International Classes:
C07K5/037; C07K1/14; A61K38/06; A61P39/06
Domestic Patent References:
WO2011132724A12011-10-27
WO2015067708A12015-05-14
WO2016159317A12016-10-06
Foreign References:
JP2016246115A2016-12-20
Other References:
MOUTIEZ M. ET AL.: "Reduction of a trisulfide derivative of glutathione by glutathione reductase", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 202, no. 3, 1994, pages 1380 - 1386, XP024766119
PURDIE J. W. ET AL.: "Chromatography of cysteine and glutathione derivatives on a Dowex 1/Sephadex mixed-bed column", J. CHROMATOGR., vol. 59, no. 1, 1971, pages 181 - 184, XP026508905
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 42, 1971, pages 730 - 738
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 202, 1994, pages 1380 - 1386
FASEB J., vol. 18, 2004, pages 1165 - 1167
J. CHROMATOGR., vol. 59, 1971, pages 181 - 184
DAVID A. ATWOODM. KAMRUZ ZAMAN: "Encyclopedia of Inorganic Chemistry", 2006, JOHN WILEY & SONS, LTD., article "Sulfur: Organic Polysulfanes"
ACTA CRYST., vol. A64, 2008, pages 112
ACTA CRYST., vol. A39, 1983, pages 876
Attorney, Agent or Firm:
EIKOH PATENT FIRM, P.C. (Toranomon East Bldg. 10F, 7-13 Nishi-Shimbashi 1-chome, Minato-k, Tokyo 03, 〒1050003, JP)
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