Title:
CRYSTALS OF GLYCINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/051056
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: crystals of (S,E)-2-(2,6-dichlorobenzamido)-5-[4-(isopropyl- pyrimidin-2-ylamino)phenyl]pent-4-enoic acid having excellent chemical and physical stability or a pharmacologically acceptable salt thereof; and a pharmaceutical use of the crystals. The present invention provides crystals of (S,E)-2-(2,6-dichlorobenzamido)-5-[4-(isopropyl-pyrimidin- 2-ylamino)phenyl]pent-4-enoic acid or a pharmacologically acceptable salt thereof.
Inventors:
SHIRAKI MOTOHIRO (JP)
MINODA TSUBASA (JP)
ASANO SHINGO (JP)
KANNO TAKAMI (JP)
TAKAHASHI HIROZUMI (JP)
MINODA TSUBASA (JP)
ASANO SHINGO (JP)
KANNO TAKAMI (JP)
TAKAHASHI HIROZUMI (JP)
Application Number:
PCT/JP2013/076275
Publication Date:
April 03, 2014
Filing Date:
September 27, 2013
Export Citation:
Assignee:
TORAY INDUSTRIES (JP)
International Classes:
C07D239/42; A61K31/505; A61P1/04; A61P17/00; A61P25/00; A61P35/02; A61P37/08
Domestic Patent References:
| WO2007145282A1 | 2007-12-21 | |||
| WO2006068213A1 | 2006-06-29 | |||
| WO2007148648A1 | 2007-12-27 | |||
| WO2007148676A1 | 2007-12-27 | |||
| WO2009139817A2 | 2009-11-19 | |||
| WO2013002364A1 | 2013-01-03 |
Foreign References:
| JP2008001635A | 2008-01-10 |
Other References:
KAZUHIDE ASHIZAWA: "Shio Kesshokei no Saitekika to Kesshoka Gijutsu", PHARM TECH JAPAN, vol. 18, no. 10, 2002, pages 81 - 96
GOULD PHILIP L.: "Salt selection for basic drugs", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 33, 1986, pages 201 - 217
GOULD PHILIP L.: "Salt selection for basic drugs", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 33, 1986, pages 201 - 217
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