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Patent Searching and Data


Title:
CRYSTALS OF β-NICOTINAMIDE MONONUCLEOTIDE AND PRODUCTION PROCESS THEREFOR
Document Type and Number:
WIPO Patent Application WO/2018/047715
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: crystals of β-nicotinamide mononucleotide (NMN) which have excellent storage stability; and a production process therefor. According to the present invention, crystals of NMN can be precipitated from an alcohol solution containing NMN dissolved therein, by allowing the solution to stand still or stirring the solution. Crystals of NMN can be precipitated from an aqueous solution containing NMN dissolved therein, by dissolving an alcohol solution in the aqueous solution.

Inventors:
SUZUKI HIDEAKI (JP)
NAGANO HIROSHI (JP)
Application Number:
PCT/JP2017/031451
Publication Date:
March 15, 2018
Filing Date:
August 31, 2017
Export Citation:
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Assignee:
KYOWA HAKKO BIO CO LTD (JP)
International Classes:
C07H19/048; A61K31/7115; A61P3/00; A61P43/00
Domestic Patent References:
WO2017059249A12017-04-06
Other References:
MIKHAILOPULO, I. A. ET AL.: "Synthesis of Glycosides of Nicotinamide and Nicotinamide Mononucleotide", SYNTHESIS, vol. 1981, no. 5, 1981, pages 388 - 389, XP055206385
MANGIN, DENIS ET AL.: "Polymorphism in Processes of Crystallization in Solution: A Practical Review", ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 13, 2009, pages 1241 - 1253, XP055283229, DOI: doi:10.1021/op900168f
STIEGER, NICOLE ET AL.: "Recrystallization of Active Pharmaceutical Ingredients", CRYSTALLIZATION - SCIENCE AND TECHNOLOGY, 2012, pages 183 - 204, XP055410247, DOI: 10.5772/52725
Attorney, Agent or Firm:
EIKOH PATENT FIRM, P.C. (JP)
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