Title:
CRYSTALS AND STRUCTURES OF SPLEEN TYROSINE KINASE SYKKD
Document Type and Number:
WIPO Patent Application WO2004058177
Kind Code:
A3
Abstract:
The present invention provides machine readable media embedded with the three-dimensional molecular structure coordinates of SYKKD and subsets thereof, including binding pockets, methods of using the structure to identify and design affecters, including inhibitors and activator, mutants of SYKKD, and compounds and compositions that affect SYK activity.
Inventors:
ATWELL SHANE (US)
HENDLE JORG (US)
BUCHANAN SEAN GRANT (US)
FEIL INGEBORG (US)
RUSSELL MARIJANE (US)
BADGER JOHN (US)
TOMIMOTO MASAKI (US)
SAUDER MICHAEL J (US)
HENDLE JORG (US)
BUCHANAN SEAN GRANT (US)
FEIL INGEBORG (US)
RUSSELL MARIJANE (US)
BADGER JOHN (US)
TOMIMOTO MASAKI (US)
SAUDER MICHAEL J (US)
Application Number:
PCT/US2003/040935
Publication Date:
May 26, 2005
Filing Date:
December 18, 2003
Export Citation:
Assignee:
STRUCTURAL GENOMIX INC (US)
ATWELL SHANE (US)
HENDLE JORG (US)
BUCHANAN SEAN GRANT (US)
FEIL INGEBORG (US)
RUSSELL MARIJANE (US)
BADGER JOHN (US)
TOMIMOTO MASAKI (US)
SAUDER MICHAEL J (US)
ATWELL SHANE (US)
HENDLE JORG (US)
BUCHANAN SEAN GRANT (US)
FEIL INGEBORG (US)
RUSSELL MARIJANE (US)
BADGER JOHN (US)
TOMIMOTO MASAKI (US)
SAUDER MICHAEL J (US)
International Classes:
C07K14/705; C12N9/12; (IPC1-7): C12N9/12; G06T15/20; G09G5/40; G11B5/84
Domestic Patent References:
| WO2004035604A2 | 2004-04-29 |
Foreign References:
| US5221410A | 1993-06-22 | |||
| US6797706B1 | 2004-09-28 |
Other References:
LITWIN C.M. ET AL: "Purification and Characterization of a pp60c-src-related Tyrosine Kinase that Effectively Phosphorylates a Synthetic Peptide Derived from p34cdc2", J. BIOL. CHEM., vol. 266, no. 4, 5 February 1991 (1991-02-05), pages 2557 - 2566, XP002985456
GOODMAN P.A. ET AL: "Spleen Tyrosine Kinase (Syk) Deficiency in Childhood pro-B Cell Acute Lymphoblastic Leukemia", ONCOGENE, vol. 20, no. 30, 5 July 2001 (2001-07-05), pages 3969 - 3978, XP002985457
CYWIN C.Y. ET AL: "Discovery and SAR of Novel [1,6]Naphthyridines as Potent Inhibitors of Spleen Tyrosine Kinase (SYK)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 8, 17 April 2003 (2003-04-17), pages 1415 - 1418, XP002985458
GOODMAN P.A. ET AL: "Spleen Tyrosine Kinase (Syk) Deficiency in Childhood pro-B Cell Acute Lymphoblastic Leukemia", ONCOGENE, vol. 20, no. 30, 5 July 2001 (2001-07-05), pages 3969 - 3978, XP002985457
CYWIN C.Y. ET AL: "Discovery and SAR of Novel [1,6]Naphthyridines as Potent Inhibitors of Spleen Tyrosine Kinase (SYK)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 8, 17 April 2003 (2003-04-17), pages 1415 - 1418, XP002985458
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