Title:
CRYSTALS OF TETRAHYDRONAPHTHYL UREA DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2019/054451
Kind Code:
A1
Abstract:
Provided are type-I, type-III, type-V and type-VI crystals of 1-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-6-(2-methylpyrimidin-5-yl)-2-phenylpyridin-3-yl) urea which are useful as bulk pharmaceutical crystals. Also provided are type-I, type-III, type-V and type-VI crystals of 1-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-6-(2-methylpyrimidin-5-yl)-2-phenylpyridin-3-yl) urea having excellent TrkA inhibitory effect, medicines and medicinal compositions containing these crystals, and a method for producing these crystals.
Inventors:
KAWADA YUJI (JP)
SAITOH FUMIHIKO (JP)
NAGASUE HIROSHI (JP)
SATOH TSUTOMU (JP)
SAITOH FUMIHIKO (JP)
NAGASUE HIROSHI (JP)
SATOH TSUTOMU (JP)
Application Number:
PCT/JP2018/034021
Publication Date:
March 21, 2019
Filing Date:
September 13, 2018
Export Citation:
Assignee:
MOCHIDA PHARM CO LTD (JP)
International Classes:
C07D401/04; A61K31/506; A61P43/00
Domestic Patent References:
| WO2014078378A1 | 2014-05-22 | |||
| WO2016116900A1 | 2016-07-28 | |||
| WO2018199166A1 | 2018-11-01 |
Foreign References:
| JP2015537001A | 2015-12-24 | |||
| JPS50108250A | 1975-08-26 |
Attorney, Agent or Firm:
TANAKA Shinichiro et al. (JP)
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