Title:
CSF-1R INHIBITORS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/241608
Kind Code:
A1
Abstract:
The present application relates to compounds of formula (I) and formula (1'), which are useful as inhibitors of CSF-1R in the treatment of various diseases.
Inventors:
WANG HAO (CN)
ZHANG ENGE (CN)
ZHAO SHUHAI (CN)
YANG MINMIN (CN)
LI PENG (CN)
GENG BOLIN (US)
SHLEVKOV EVGENY (US)
ONG TA REN (US)
WANG JING YU (US)
LIN YEN-CHEN (US)
YOUNG MICHAEL NAKAMURA (US)
HARVEY LAUREN MARIE (US)
CHEN YI ALEX (US)
HAN XIAO (US)
ZHANG ENGE (CN)
ZHAO SHUHAI (CN)
YANG MINMIN (CN)
LI PENG (CN)
GENG BOLIN (US)
SHLEVKOV EVGENY (US)
ONG TA REN (US)
WANG JING YU (US)
LIN YEN-CHEN (US)
YOUNG MICHAEL NAKAMURA (US)
HARVEY LAUREN MARIE (US)
CHEN YI ALEX (US)
HAN XIAO (US)
Application Number:
PCT/CN2023/100107
Publication Date:
December 21, 2023
Filing Date:
June 14, 2023
Export Citation:
Assignee:
MYROBALAN THERAPEUTICS NANJING CO LTD (CN)
MYROBALAN THERAPEUTICS INC (US)
MYROBALAN THERAPEUTICS INC (US)
International Classes:
A61P3/00; A61K31/437; A61K31/4375; A61K31/444; A61K31/47; A61K31/4709; A61K31/501; A61K31/517; A61K31/519; A61K31/553; A61P25/28; A61P29/00; A61P35/00; A61P37/00; C07D215/14; C07D215/20; C07D239/74; C07D401/12; C07D401/14; C07D405/12; C07D413/12; C07D417/12; C07D471/04; C07D519/00
Domestic Patent References:
| WO2021144360A1 | 2021-07-22 | |||
| WO2021170078A1 | 2021-09-02 | |||
| WO2018119387A1 | 2018-06-28 |
Foreign References:
| EP3738961A1 | 2020-11-18 | |||
| US5236952A | 1993-08-17 |
Other References:
J CELL BIOCHEM., vol. 38, no. 3, 1988, pages 179 - 87
IMMUNITY., vol. 41, no. 1, 2014, pages 49 - 61
NAT MED., vol. 19, no. 10, 2013, pages 1264 - 72
N ENGL J MED., vol. 373, no. 5, 2015, pages 428 - 37
ARTHRITIS RES THER., vol. 18, no. 75, 2016
NAT REV IMMUNOL., vol. 8, no. 7, 2008, pages 533 - 44
J IMMUNOTHER CANCER., vol. 5, no. 1, 2017, pages 53
NEUROBIOL AGING., vol. 21, 2000, pages 383 - 421
BRAIN RES., vol. 639, 1994, pages 171 - 4
BRAIN., vol. 139, 2016, pages 891 - 907
S. M. BERGE ET AL.: "pharmacologically acceptable salts", J. PHARM. SCI., vol. 66, 1977, pages 1 - 19
FINNINMORGAN, J. PHARM. SCI., vol. 88, 1999, pages 955 - 958
HOOVER, JOHN E.: "Remington's Pharmaceutical Sciences", 1975, MACK PUBLISHING CO.
LIBERMAN ET AL.: "Pharmaceutical Dosage Forms", 1980, MARCEL DECKER
KIBBE ET AL.: "Handbook of Pharmaceutical Excipients", 1999, AMERICAN PHARMACEUTICAL ASSOCIATION
PERGAMONREMINGTON: "Comprehensive Organic Transformations: A Guide to Functional Group Preparations", vol. 1-12, 1991, JOHN WILEY AND SONS
IMMUNITY., vol. 41, no. 1, 2014, pages 49 - 61
NAT MED., vol. 19, no. 10, 2013, pages 1264 - 72
N ENGL J MED., vol. 373, no. 5, 2015, pages 428 - 37
ARTHRITIS RES THER., vol. 18, no. 75, 2016
NAT REV IMMUNOL., vol. 8, no. 7, 2008, pages 533 - 44
J IMMUNOTHER CANCER., vol. 5, no. 1, 2017, pages 53
NEUROBIOL AGING., vol. 21, 2000, pages 383 - 421
BRAIN RES., vol. 639, 1994, pages 171 - 4
BRAIN., vol. 139, 2016, pages 891 - 907
S. M. BERGE ET AL.: "pharmacologically acceptable salts", J. PHARM. SCI., vol. 66, 1977, pages 1 - 19
FINNINMORGAN, J. PHARM. SCI., vol. 88, 1999, pages 955 - 958
HOOVER, JOHN E.: "Remington's Pharmaceutical Sciences", 1975, MACK PUBLISHING CO.
LIBERMAN ET AL.: "Pharmaceutical Dosage Forms", 1980, MARCEL DECKER
KIBBE ET AL.: "Handbook of Pharmaceutical Excipients", 1999, AMERICAN PHARMACEUTICAL ASSOCIATION
PERGAMONREMINGTON: "Comprehensive Organic Transformations: A Guide to Functional Group Preparations", vol. 1-12, 1991, JOHN WILEY AND SONS
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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