Title:
CTLA4 ANTIBODY, PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/165895
Kind Code:
A1
Abstract:
Provided is an isolated CTLA4 monoclonal antibody. The antibody can highly-specifically bind to CTLA4, and can effectively block the binding of CLTA4 to B7, reduce the activity or expression level of CTLA4, relieve the inhibition of CTLA4 on the immune function of an organism, activate T lymphocytes, and effectively treat tumours and immune system diseases. Also provided are a monoclonal antibody conjugate comprising the pharmaceutical composition and diagnostic composition of the antibody, and the use thereof in the preparation of a drug for preventing and/or treating and/or treating in combination tumours and immune system diseases.
Inventors:
ZHOU HONGLIN (CN)
DONG XIN (CN)
LIU JIE (CN)
CAI BIN (CN)
DONG XIN (CN)
LIU JIE (CN)
CAI BIN (CN)
Application Number:
PCT/CN2017/076751
Publication Date:
September 20, 2018
Filing Date:
March 15, 2017
Export Citation:
Assignee:
SUZHOU GALAXY BIOPHARMA CO LTD (CN)
International Classes:
A61K39/395; C12N5/20; A61P35/00; A61P37/00; C07K16/28; C12N15/13
Foreign References:
| US5977318A | 1999-11-02 | |||
| CN103547595A | 2014-01-29 | |||
| CN105296433A | 2016-02-03 |
Other References:
CHUNLIAN ET AL.: "Progress in the Study of CTLA-4 Monoclonal Antibodies", CHINESE JOURNAL OF CELLULAR AND MOLECULAR IMMUNOLOGY, vol. 7, 31 December 2013 (2013-12-31), pages 769 - 771, XP009516821, ISSN: 1007-8738
ZHOU H ET AL., NUCLEIC ACIDS RESEARCH, vol. 22, 1994, pages 888 - 889
CHARDES T ET AL., FEBS LETTERS, vol. 452, 1999, pages 386 - 394
KABAT E.A. ET AL.: "NIH Publication", 1991, US DEPARTMENT OF HEALTH AND HUMAN SERVICES, article "Sequences of proteins of immunological interest"
CARTER P ET AL., PNAS, vol. 89, 1992, pages 4285 - 4289
PRESTA LG ET AL., CANCER RESEARCH, vol. 57, 1997, pages 4593 - 4599
See also references of EP 3597735A4
ZHOU H ET AL., NUCLEIC ACIDS RESEARCH, vol. 22, 1994, pages 888 - 889
CHARDES T ET AL., FEBS LETTERS, vol. 452, 1999, pages 386 - 394
KABAT E.A. ET AL.: "NIH Publication", 1991, US DEPARTMENT OF HEALTH AND HUMAN SERVICES, article "Sequences of proteins of immunological interest"
CARTER P ET AL., PNAS, vol. 89, 1992, pages 4285 - 4289
PRESTA LG ET AL., CANCER RESEARCH, vol. 57, 1997, pages 4593 - 4599
See also references of EP 3597735A4
Attorney, Agent or Firm:
BEIJING ARETE INTELLECTUAL PROPERTY AGENCY (CN)
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