CUCURBITACIN B DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF

Title:

CUCURBITACIN B DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/169372

Kind Code:

A1

Abstract:

A cucurbitacin B derivative, a preparation method therefor and a use thereof. The structure of the compound is shown in formula I. The cucurbitacin B derivative is easy to synthesize, has good anti-tumor and anti-inflammatory activity, and can be used for preparing anti-tumor and anti-inflammatory drugs.

Inventors:

NAN FAJUN (CN)
LI JINGYA (CN)
ZHUO NING (CN)
CAO LEI (CN)
SUN XINYU (CN)
MA JIE (CN)
KONG XIANGRONG (CN)

Application Number:

PCT/CN2023/079902

Publication Date:

September 14, 2023

Filing Date:

March 06, 2023

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Assignee:

SHANGHAI INST MATERIA MEDICA CAS (CN)

International Classes:

C07J9/00; A61K31/575; A61P29/00; A61P35/00

Domestic Patent References:

WO2002078617A2	2002-10-10
WO2009024103A2	2009-02-26

Foreign References:

CN102659888A	2012-09-12
CN103360452A	2013-10-23
US20190144492A1	2019-05-16

Other References:

ZHUO, NING: "Design and Synthesis of Intestinal-restricted TGR5 Agonists Based on Pentacyclic Triterpene Skeleton and Diversified Transformation of Cucurbitacin B", CHINA DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, MEDICINE & PUBLIC HEALTH, no. 02, 15 February 2023 (2023-02-15)

Attorney, Agent or Firm:

XU & PARTNERS , LLC. (CN)

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