Title:
CURCUMIN-CONTAINING LIPID NANOPARTICLE COMPLEX COMPRISING GINSENOSIDES
Document Type and Number:
WIPO Patent Application WO/2017/095138
Kind Code:
A1
Abstract:
In order to improve the stability, dispersibility, and bioavailability of curcumin, the present invention relates to a lipid nanoparticle comprising ginsenosides and phospholipids; a method for preparing the lipid nanoparticle; a pharmaceutical composition for preventing or treating cancer comprising the lipid nanoparticle; an anti-oxidant food composition, a feed composition, and a cosmetic composition. As the curcumin-containing lipid nanoparticle provided by the present invention improves the stability, dispersibility, and bioavailability by using ginsenosides, the curcumin-containing lipid nanoparticle can be widely used in the development of various curcumin-containing products.
Inventors:
YOO BONG KYU (KR)
BAEK JEONG-HEUM (KR)
KIM HWAN MOOK (KR)
CHUNG JUN WON (KR)
OH SEUNG HYUN (KR)
BASKARAN RENGARAJAN (KR)
SYM SUN JIN (KR)
PARK IN KEUN (KR)
BAEK JEONG-HEUM (KR)
KIM HWAN MOOK (KR)
CHUNG JUN WON (KR)
OH SEUNG HYUN (KR)
BASKARAN RENGARAJAN (KR)
SYM SUN JIN (KR)
PARK IN KEUN (KR)
Application Number:
PCT/KR2016/013964
Publication Date:
June 08, 2017
Filing Date:
November 30, 2016
Export Citation:
Assignee:
GIL MEDICAL CT (KR)
GACHON UNIV OF INDUSTRY-ACADEMIC COOP FOUND (KR)
GACHON UNIV OF INDUSTRY-ACADEMIC COOP FOUND (KR)
International Classes:
A23L33/10; A23K20/00; A61K8/35; A61K8/55; A61K8/60; A61Q19/00
Foreign References:
| CN101530389A | 2009-09-16 | |||
| KR101423269B1 | 2014-07-25 | |||
| US20090324703A1 | 2009-12-31 |
Other References:
SHELAT, PRAGNA ET AL.: "Formulation of curcuminoid loaded solid lipid nanoparticles in order to improve oral bioavailability", INTERNATIONAL JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, vol. 7, no. Issue 6, June 2015 (2015-06-01), pages 278 - 282
SUN, JIABEI ET AL.: "Curcumin-loaded solid lipid nanoparticles have prolonged in vitro antitumour activity, cellular uptake and improved in vivo bioavailability", COLLOIDS AND SURFACES B: BIOINTERFACES, vol. 111, 25 June 2013 (2013-06-25), pages 367 - 375, XP029056529
SUN, JIABEI ET AL.: "Curcumin-loaded solid lipid nanoparticles have prolonged in vitro antitumour activity, cellular uptake and improved in vivo bioavailability", COLLOIDS AND SURFACES B: BIOINTERFACES, vol. 111, 25 June 2013 (2013-06-25), pages 367 - 375, XP029056529
Attorney, Agent or Firm:
SON, Min (KR)
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