Title:
CXCL-MODULATING COMPOSITIONS AND METHODS
Document Type and Number:
WIPO Patent Application WO/2023/192911
Kind Code:
A3
Abstract:
The present disclosure relates to expression repressors decreasing expression of a target plurality of genes in a cell. In some embodiments, the target plurality of genes comprises CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL7, and IL-8. In some embodiments, the expression repressor targets the E1 cRE of the CXCL locus. In some embodiments, the expression repressor targets the E2 cRE of the CXCL locus.
Inventors:
BELAGHZAL HOUDA (US)
NGUYEN LAURA ANH (US)
FARELLI JEREMIAH DALE (US)
NEWMAN JOSEPH (US)
BEECH LAUREN MARIE (US)
JHA MITHILESH K (US)
O'DONNELL CHARLES (US)
NGUYEN LAURA ANH (US)
FARELLI JEREMIAH DALE (US)
NEWMAN JOSEPH (US)
BEECH LAUREN MARIE (US)
JHA MITHILESH K (US)
O'DONNELL CHARLES (US)
Application Number:
PCT/US2023/065108
Publication Date:
October 26, 2023
Filing Date:
March 29, 2023
Export Citation:
Assignee:
FLAGSHIP PIONEERING INNOVATIONS V INC (US)
BELAGHZAL HOUDA (US)
BELAGHZAL HOUDA (US)
International Classes:
C12N15/113; A61K31/7088; A61K9/51; A61K35/17; A61P31/14; A61P35/00
Domestic Patent References:
| WO2014003742A1 | 2014-01-03 |
Foreign References:
| US20210301349A1 | 2021-09-30 | |||
| US20090041753A1 | 2009-02-12 | |||
| US6444801B1 | 2002-09-03 |
Other References:
THE SANGER CENTRE (UK) AND THE WASHINGTON UNIVERSITY GENOME SEQUENCING CENTER (USA): "Toward a complete human genome sequence.", GENOME RESEARCH, COLD SPRING HARBOR LABORATORY PRESS, US, vol. 8, no. 11, 1 November 1998 (1998-11-01), US , pages 1097 - 1108, XP002169000, ISSN: 1088-9051
Attorney, Agent or Firm:
KOYFMAN, Hannah R. (US)
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