Title:
CYANINE-TREHALOSE COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/216992
Kind Code:
A1
Abstract:
Provided are a cyanine-trehalose compound, a method for preparing same, and use thereof. Specifically, the compound is represented by formula I. The cyanine-trehalose compound can be used for detecting Mycobacterium tuberculosis, and features high fluorescence intensity, low background, specificity, and good stability.
Inventors:
LIU GANG (CN)
LI XUEYUAN (CN)
LI XUEYUAN (CN)
Application Number:
PCT/CN2023/092287
Publication Date:
November 16, 2023
Filing Date:
May 05, 2023
Export Citation:
Assignee:
HANGZHOU COMBIREG PHARMATECH CO LTD (CN)
International Classes:
C07D277/64; A61K31/7016; C07D235/20; C07D413/06; C07D417/06; C07H5/06; C09B23/00; G01N33/533; G01N33/569
Domestic Patent References:
| WO2014152718A1 | 2014-09-25 | |||
| WO2016052621A1 | 2016-04-07 | |||
| WO2019211705A1 | 2019-11-07 |
Foreign References:
| US6828116B1 | 2004-12-07 | |||
| JPH03504661A | 1991-10-09 | |||
| CN109627320A | 2019-04-16 |
Other References:
YU ZHIQIANG, PAUL RAKESH, BHATTACHARYA CHANDRABALI, BOZEMAN TREVOR C., RISHEL MICHAEL J., HECHT SIDNEY M.: "Structural Features Facilitating Tumor Cell Targeting and Internalization by Bleomycin and Its Disaccharide", BIOCHEMISTRY, vol. 54, no. 19, 19 May 2015 (2015-05-19), pages 3100 - 3109, XP093108717, ISSN: 0006-2960, DOI: 10.1021/acs.biochem.5b00277
BHATTACHARYA CHANDRABALI, YU ZHIQIANG, RISHEL MICHAEL J., HECHT SIDNEY M.: "The Carbamoylmannose Moiety of Bleomycin Mediates Selective Tumor Cell Targeting", BIOCHEMISTRY, vol. 53, no. 20, 27 May 2014 (2014-05-27), pages 3264 - 3266, XP093108720, ISSN: 0006-2960, DOI: 10.1021/bi500482q
MADATHIL MANIKANDADAS M., BHATTACHARYA CHANDRABALI, YU ZHIQIANG, PAUL RAKESH, RISHEL MICHAEL J., HECHT SIDNEY M.: "Modified Bleomycin Disaccharides Exhibiting Improved Tumor Cell Targeting", BIOCHEMISTRY, vol. 53, no. 43, 4 November 2014 (2014-11-04), pages 6800 - 6810, XP093108721, ISSN: 0006-2960, DOI: 10.1021/bi501102z
BHATTACHARYA CHANDRABALI, YU ZHIQIANG, RISHEL MICHAEL J., HECHT SIDNEY M.: "The Carbamoylmannose Moiety of Bleomycin Mediates Selective Tumor Cell Targeting", BIOCHEMISTRY, vol. 53, no. 20, 27 May 2014 (2014-05-27), pages 3264 - 3266, XP093108720, ISSN: 0006-2960, DOI: 10.1021/bi500482q
MADATHIL MANIKANDADAS M., BHATTACHARYA CHANDRABALI, YU ZHIQIANG, PAUL RAKESH, RISHEL MICHAEL J., HECHT SIDNEY M.: "Modified Bleomycin Disaccharides Exhibiting Improved Tumor Cell Targeting", BIOCHEMISTRY, vol. 53, no. 43, 4 November 2014 (2014-11-04), pages 6800 - 6810, XP093108721, ISSN: 0006-2960, DOI: 10.1021/bi501102z
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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