Title:
CYANO THIENOTRIAZOLODIAZEPINES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/044849
Kind Code:
A8
Abstract:
The present invention provides compounds and pharmaceutically compositions thereof. The compounds and compositions are binders of bromodomains and/or bromodomain-containing proteins (e.g., bromo and extra terminal (BET) proteins). Also provided are methods, uses, and kits using the compounds and pharmaceutical compositions for inhibiting the activity (e.g., increased activity) of bromodomains and/or bromodomain-containing proteins and for treating and/or preventing in a subject diseases associated with bromodomains or bromodomain-containing proteins (e.g., proliferative diseases, cardiovascular diseases, viral infections, fibrotic diseases, metabolic diseases, endocrine diseases, and radiation poisoning). The compounds, pharmaceutical compositions, and kits are also useful for male contraception.
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Inventors:
BRADNER JAMES E (US)
QI JUN (US)
TANAKA MINORU (US)
BUCKLEY DENNIS (US)
QI JUN (US)
TANAKA MINORU (US)
BUCKLEY DENNIS (US)
Application Number:
PCT/US2016/051107
Publication Date:
September 28, 2017
Filing Date:
September 09, 2016
Export Citation:
Assignee:
DANA FARBER CANCER INST INC (US)
International Classes:
A61K31/551; A61K31/55; C07D243/00; C07D243/10; C07D495/14
Attorney, Agent or Firm:
BAKER, C., Hunter (US)
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