Title:
CYANOPYRROLES AS PROGESTERONE RECEPTOR AGONISTS
Document Type and Number:
WIPO Patent Application WO2000066581
Kind Code:
A8
Abstract:
This invention provides a progesterone receptor antagonist of formula (1) having the structure wherein T is O, S, or absent; R1, and R2 are each, independently, hydrogen, alkyl, substituted alkyl; or R1 and R2 are taken together to form a ring and together contain -CH2(CH2)nCH2-, -CH2CH2CMe2CH2CH2-, -O(CH2)pCH2-, -O(CH2)qO-, -CH2CH2OCH2CH2-, or -CH2CH2NR7CH2CH2-; n=1-5; p=1-4; q=1-4; R3 is hydrogen, OH, NH2, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or COR; R is hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R4 is hydrogen, halogen, CN, NH2, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R5 is hydrogen, alkyl, or substituted alkyl; R6 is hydrogen, alkyl, substituted alkyl, or COR; R is hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R7 is hydrogen or alkyl; or a pharmaceutically acceptable salt thereof.
Inventors:
COLLINS MARK A (US)
MACKNER VALERIE A (US)
ZHI LIN (US)
JONES TODD K (US)
TEGLEY CHRISTOPHER M (US)
WROBEL JAY E (US)
EDWARDS JAMES P (US)
MACKNER VALERIE A (US)
ZHI LIN (US)
JONES TODD K (US)
TEGLEY CHRISTOPHER M (US)
WROBEL JAY E (US)
EDWARDS JAMES P (US)
Application Number:
PCT/US2000/011844
Publication Date:
May 30, 2002
Filing Date:
May 01, 2000
Export Citation:
Assignee:
AMERICAN HOME PROD (US)
LIGAND PHARM INC (US)
COLLINS MARK A (US)
MACKNER VALERIE A (US)
ZHI LIN (US)
JONES TODD K (US)
TEGLEY CHRISTOPHER M (US)
WROBEL JAY E (US)
EDWARDS JAMES P (US)
LIGAND PHARM INC (US)
COLLINS MARK A (US)
MACKNER VALERIE A (US)
ZHI LIN (US)
JONES TODD K (US)
TEGLEY CHRISTOPHER M (US)
WROBEL JAY E (US)
EDWARDS JAMES P (US)
International Classes:
C07D403/04; A61K31/40; A61K31/403; A61K31/404; A61K31/405; A61K31/536; A61K31/5415; A61P5/34; A61P13/08; A61P15/00; A61P15/14; A61P15/16; A61P15/18; A61P35/00; A61P43/00; C07D413/04; (IPC1-7): C07D413/04; C07D403/04; A61K31/40; A61P15/16
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