CYCLAM DERIVATIVE COMPOUND AND PHARMACEUTICAL USE THEREOF

Title:

CYCLAM DERIVATIVE COMPOUND AND PHARMACEUTICAL USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2016/114634

Kind Code:

A3

Abstract:

The present invention relates to a cyclam derivative compound and a pharmaceutical use thereof. The cyclam derivative compound can alleviate side effects of a drug since the compound enables an efficient drug delivery by selectively recognizing CXCR4 which is over-expressed on surfaces of cancer cells; can reduce the toxicity of non-selective drug delivery; and can enhance the effectiveness of the drug in a target cell.

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Inventors:

OH YU-KYOUNG (KR)
KIM JINYOUNG (KR)
HAN JEONGHOON (KR)
KIM GUNWOO (KR)

Application Number:

PCT/KR2016/000478

Publication Date:

October 27, 2016

Filing Date:

January 15, 2016

Export Citation:

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Assignee:

UNIV SEOUL NAT R & DB FOUND (KR)

International Classes:

C07D257/02; A61K31/41; A61K47/30; A61K47/48; C07D403/10

Foreign References:

KR20110039557A	2011-04-19
US20070043012A1	2007-02-22
US20140243397A1	2014-08-28
US20090202435A1	2009-08-13

Other References:

LE BON, B. ET AL.: "AMD3100 Conjugates as Components of Targeted Nonvira] Gene Delivery Systems: Synthesis and in Vitro Transfecticn Efficiency of CXCR4-Expressing Cells", BIOCONJUGATE CHEM., vol. 15, no. 2, 2004, pages 413 - 423, XP002398953

Attorney, Agent or Firm:

DANA PATENT LAW FIRM (New Wing Gwangsung Bldg.,11, Yeoksam-ro 3-gil,Gangnam-gu, Seoul, KR)

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