Title:
Cyclic Ureas
Document Type and Number:
WIPO Patent Application WO/2020/103884
Kind Code:
A1
Abstract:
Amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
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Inventors:
SU YANING (CN)
ZHANG ZHIYUAN (CN)
HAN JIANGUANG (CN)
RUAN HANYING (CN)
LI YING (CN)
WANG GUOZHENG (CN)
LIU WENDONG (CN)
ZHANG CHONG (CN)
LIANG LEIMING (CN)
ZHANG ZHIYUAN (CN)
HAN JIANGUANG (CN)
RUAN HANYING (CN)
LI YING (CN)
WANG GUOZHENG (CN)
LIU WENDONG (CN)
ZHANG CHONG (CN)
LIANG LEIMING (CN)
Application Number:
PCT/CN2019/119795
Publication Date:
May 28, 2020
Filing Date:
November 20, 2019
Export Citation:
Assignee:
SU YANING (CN)
SIRONAX LTD (GB)
SIRONAX LTD (GB)
International Classes:
C07D231/06; A61K31/397; A61K31/4155; A61P43/00; C07D205/04
Domestic Patent References:
| WO2003079973A2 | 2003-10-02 |
Foreign References:
| US20120122889A1 | 2012-05-17 |
Other References:
CHRISTOPHER D. COX ET AL : "Kinesin spindle protein (KSP) inhibitors. Part 4:^1 Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, no. 12, 15 June 2006 (2006-06-15), pages 3175 - 3179, XP025106203, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2006.03.040
SEBASTIAN JOMON: "Dihydropyrazole and dihydropyrrole structures based design of Kif15 inhibitors as novel therapeutic agents for cancer", COMPUTATIONAL BIOLOGY AND CHEMISTRY, vol. 68, 12 March 2017 (2017-03-12), pages 164 - 174, XP085013569, ISSN: 1476-9271, DOI: 10.1016/j.compbiolchem.2017.03.006
SEBASTIAN JOMON: "Dihydropyrazole and dihydropyrrole structures based design of Kif15 inhibitors as novel therapeutic agents for cancer", COMPUTATIONAL BIOLOGY AND CHEMISTRY, vol. 68, 12 March 2017 (2017-03-12), pages 164 - 174, XP085013569, ISSN: 1476-9271, DOI: 10.1016/j.compbiolchem.2017.03.006
Attorney, Agent or Firm:
PANAWELL & PARTNERS, LLC (CN)
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