Title:
CYCLIC AMIDE COMPOUNDS FOR RABIES TREATMENT AND METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/246503
Kind Code:
A1
Abstract:
The present disclosure provides compounds useful in the treatment and prevention of rabies. The present disclosure provides compounds represented by formula XXIF or XXIB [in the formulas, R1, R2A, R2B, R3, and R4 are as defined in the specification], solvates or pharmaceutically acceptable salts thereof, the use of these compounds, solvates or pharmaceutically acceptable salts thereof to treat or prevent rabies, pharmaceutical compositions including these compounds, solvates or pharmaceutically acceptable salts thereof, and a method for treating and preventing rabies using the same.
Inventors:
MATSUOKA SHIGERU (JP)
KATO AKIRA (JP)
MISHINA TADASHI (JP)
YAMADA KENTARO (JP)
YOSHIMORI ATSUSHI (JP)
ISHIZAKI TOSHIMASA (JP)
NISHIZONO AKIRA (JP)
KOUJI HIROYUKI (JP)
KATO AKIRA (JP)
MISHINA TADASHI (JP)
YAMADA KENTARO (JP)
YOSHIMORI ATSUSHI (JP)
ISHIZAKI TOSHIMASA (JP)
NISHIZONO AKIRA (JP)
KOUJI HIROYUKI (JP)
Application Number:
PCT/JP2020/021940
Publication Date:
December 10, 2020
Filing Date:
June 03, 2020
Export Citation:
Assignee:
OITA UNIV INSTITUTE OF ADVANCED MEDICINE INC (JP)
International Classes:
A61P31/14; A61K31/439; C07D471/18
Domestic Patent References:
| WO2020036211A1 | 2020-02-20 |
Foreign References:
| US6110973A | 2000-08-29 | |||
| US5731000A | 1998-03-24 | |||
| US5541231A | 1996-07-30 | |||
| US5427798A | 1995-06-27 | |||
| US5358970A | 1994-10-25 | |||
| US4172896A | 1979-10-30 | |||
| US20050080056A1 | 2005-04-14 | |||
| US20050059744A1 | 2005-03-17 | |||
| US20050031697A1 | 2005-02-10 | |||
| US20050004074A1 | 2005-01-06 | |||
| US6583124B2 | 2003-06-24 | |||
| US3845770A | 1974-11-05 | |||
| US3916899A | 1975-11-04 | |||
| US3536809A | 1970-10-27 | |||
| US3598123A | 1971-08-10 | |||
| US4008719A | 1977-02-22 | |||
| US5674533A | 1997-10-07 | |||
| US5059595A | 1991-10-22 | |||
| US5591767A | 1997-01-07 | |||
| US5120548A | 1992-06-09 | |||
| US5073543A | 1991-12-17 | |||
| US5639476A | 1997-06-17 | |||
| US5354556A | 1994-10-11 | |||
| US5733566A | 1998-03-31 | |||
| JP2019103958A | 2019-06-27 | |||
| JP2020023653A | 2020-02-13 |
Other References:
SARAH MURRISON; SUSHIL K MAURYA; CHRISTIAN EINZINGER; BEN MCKEEVER-ABBAS; STUART WARRINER; ADAM NELSON: "Synthesis of Skeletally Diverse Alkaloid-Like Small Molecules", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2011, pages 2354 - 2359, XP055687632
CRAVEN PHILIP; AIMON ANTHONY; DOW MARK; FLEURY-BREGEOT NICOLAS; GUILLEUX RACHEL; MORGENTIN REMY; ROCHE DIDIER; KALLIOKOSKI TUOMO; : "Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like libraries", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, no. 11, 2015, pages 2629 - 2635, XP029226477
WILLIAM J. BROMLEY, MAIRI GIBSON, STUART LANG, STEVEN A. RAW,, ADRIAN C. WHITWOOD AND RICHARD J. K. TAYLOR: "Tandem inverse electron demand Diels–Alder, retro-Diels–Alder and intramolecular Diels–Alder sequences: one-pot synthesis of diaza-polycycles", TETRAHEDRON, vol. 63, no. 26, 2007, pages 6004 - 6014, XP022093121
PETER G. M. WUTS: "Greene's Protective Groups in Organic Synthesis", 2014, JOHN WILEY & SONS, INC.
BIOORG. MED. CHEM., vol. 23, 2015, pages 2629 - 2635
ISSELBACHER ET AL., HARRISON'S PRINCIPLES OF INTERNAL MEDICINE, 1996
R. C. LAROCK: "Comprehensive Organic Transformations", 1999, JOHN WILEY AND SONS, INC.
C. W. CHEUNGM. L. PLOEGERX. HU, NATURE COMMUNICATIONS, vol. 8, 2017, pages 14878
TETRAHEDRON, vol. 63, 2007, pages 6004 - 6014
EUR. J. ORG. CHEM., 2009, pages 2185 - 2189
EUR. J. ORG. CHEM., 2011, pages 2354 - 2359
RSC ADVANCES, vol. 2, 2012, pages 5536 - 5538
TETRAHEDRON LETT., vol. 50, 2009, pages 3436 - 3438
TETRAHEDRON LETT, vol. 50, 2009, pages 3436 - 3438
"Remington's Pharmaceutical Sciences", 1990, MACK PUBLISHING
"Introduction to Pharmaceutical Dosage Forms", 1985, LEA FEBIGER
See also references of EP 3978076A4
CRAVEN PHILIP; AIMON ANTHONY; DOW MARK; FLEURY-BREGEOT NICOLAS; GUILLEUX RACHEL; MORGENTIN REMY; ROCHE DIDIER; KALLIOKOSKI TUOMO; : "Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like libraries", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, no. 11, 2015, pages 2629 - 2635, XP029226477
WILLIAM J. BROMLEY, MAIRI GIBSON, STUART LANG, STEVEN A. RAW,, ADRIAN C. WHITWOOD AND RICHARD J. K. TAYLOR: "Tandem inverse electron demand Diels–Alder, retro-Diels–Alder and intramolecular Diels–Alder sequences: one-pot synthesis of diaza-polycycles", TETRAHEDRON, vol. 63, no. 26, 2007, pages 6004 - 6014, XP022093121
PETER G. M. WUTS: "Greene's Protective Groups in Organic Synthesis", 2014, JOHN WILEY & SONS, INC.
BIOORG. MED. CHEM., vol. 23, 2015, pages 2629 - 2635
ISSELBACHER ET AL., HARRISON'S PRINCIPLES OF INTERNAL MEDICINE, 1996
R. C. LAROCK: "Comprehensive Organic Transformations", 1999, JOHN WILEY AND SONS, INC.
C. W. CHEUNGM. L. PLOEGERX. HU, NATURE COMMUNICATIONS, vol. 8, 2017, pages 14878
TETRAHEDRON, vol. 63, 2007, pages 6004 - 6014
EUR. J. ORG. CHEM., 2009, pages 2185 - 2189
EUR. J. ORG. CHEM., 2011, pages 2354 - 2359
RSC ADVANCES, vol. 2, 2012, pages 5536 - 5538
TETRAHEDRON LETT., vol. 50, 2009, pages 3436 - 3438
TETRAHEDRON LETT, vol. 50, 2009, pages 3436 - 3438
"Remington's Pharmaceutical Sciences", 1990, MACK PUBLISHING
"Introduction to Pharmaceutical Dosage Forms", 1985, LEA FEBIGER
See also references of EP 3978076A4
Attorney, Agent or Firm:
YAMAMOTO, Shusaku et al. (JP)
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