Title:
CYCLIC AMINE DERIVATIVES HAVING SEROTONIN RECEPTOR BINDING ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2022/145408
Kind Code:
A1
Abstract:
The present invention provides compounds that have a serotonin 5-HT2A receptor antagonist and/or inverse agonist activity, and pharmaceutically acceptable salts thereof, and also provides a serotonin 5-HT2A receptor antagonist and/or inverse agonist composition that contains such a compound or salt. Provided are compounds represented by formula (I): (in the formula, R1 is a substituted or unsubstituted aromatic heterocyclic group, etc.; each R2 is independently a hydrogen atom, etc.; each R3 is independently a hydrogen atom, etc.; n is 1, etc.; the combination of (L1, L2) is (NH,N), etc.; R4 is a group represented by the formula (AAA): (in the formula, p and q are each independently 2, etc., Ra is substituted or unsubstituted alkyl, etc., each Xb is independently CRbRb', each Rb is independently a hydrogen atom, etc., each Rb' is independently a hydrogen atom, etc., each Xc is independently CRcRc', each Rc is independently a hydrogen atom, etc., each Rc' is independently a hydrogen atom, etc., Xd is CRd, etc., and Rd is a hydrogen atom, etc.); R5 and R6 are each independently a hydrogen atom, etc.; and R7 is a group represented by formula (BBB): (in the formula, A is CR11, etc., R9 is substituted or unsubstituted alkyloxy, etc., R10 is a hydrogen atom, etc., and each R11 is independently a hydrogen atom, etc.)), and pharmaceutically acceptable salts thereof.
Inventors:
NAKAHARA KENJI (JP)
Application Number:
PCT/JP2021/048476
Publication Date:
July 07, 2022
Filing Date:
December 27, 2021
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
C07D261/08; A61K31/4155; A61K31/4535; A61K31/454; A61K31/4545; A61K31/497; A61K31/506; A61K31/55; A61P25/14; A61P25/16; A61P25/28; A61P43/00; C07D401/12; C07D403/12; C07D405/14; C07D409/12; C07D413/12; C07D417/12
Foreign References:
| CN113549006A | 2021-10-26 | |||
| JP2005533799A | 2005-11-10 | |||
| EP0585500A1 | 1994-03-09 | |||
| JP2020531505A | 2020-11-05 |
Other References:
DATABASE REGISTRY 17 November 2006 (2006-11-17), ANONYMOUS : "Urea, N-(2-furanylmethyl)-N'-[1-[(7-methoxy-1,3-benzodioxol-5-yl)methyl]-3- pyrrolidinyl]-N-[[4-(1-methylethoxy)phenyl]methyl]- (CA INDEX NAME)", XP055948312, retrieved from STN Database accession no. 913491-72-2
Attorney, Agent or Firm:
SUGITA Ken-ichi et al. (JP)
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