Title:
CYCLIC AMINE DERIVATIVES AND THEIR USE AS DRUGS
Document Type and Number:
WIPO Patent Application WO1999025686
Kind Code:
B1
Abstract:
A compound represented by general formula (I), a pharmaceutically acceptable acid addition salt thereof or a pharmaceutically acceptable C1-C6 alkyl addition salt thereof, and their medical applications. Since these compounds inhibit the action of chemokines such as MIP-1 alpha and/or MCP-1 on target cells, they may be useful as a therapeutic drug and/or preventative drug in diseases, such as atherosclerosis, rheumatoid arthritis, and the like where blood monocytes and lymphocytes infiltrate into tissues.
Inventors:
SHIOTA TATSUKI (JP)
KATAOKA KEN-ICHIRO (JP)
IMAI MINORU (JP)
TSUTSUMI TAKAHARU (JP)
SUDOH MASAKI (JP)
SOGAWA RYO (JP)
MORITA TAKUYA (JP)
HADA TAKAHIKO (JP)
MUROGA YUMIKO (JP)
TAKENOUCHI OSAMI (JP)
FURUYA MONORU (JP)
ENDO NORIAKI (JP)
TARBY CHRISTINE M (US)
MOREE WILNA (US)
TEIG STEVEN L (US)
KATAOKA KEN-ICHIRO (JP)
IMAI MINORU (JP)
TSUTSUMI TAKAHARU (JP)
SUDOH MASAKI (JP)
SOGAWA RYO (JP)
MORITA TAKUYA (JP)
HADA TAKAHIKO (JP)
MUROGA YUMIKO (JP)
TAKENOUCHI OSAMI (JP)
FURUYA MONORU (JP)
ENDO NORIAKI (JP)
TARBY CHRISTINE M (US)
MOREE WILNA (US)
TEIG STEVEN L (US)
Application Number:
PCT/US1998/023254
Publication Date:
July 08, 1999
Filing Date:
November 17, 1998
Export Citation:
Assignee:
TEIJIN LTD (JP)
COMBICHEM INC (US)
SHIOTA TATSUKI (JP)
KATAOKA KEN ICHIRO (JP)
IMAI MINORU (JP)
TSUTSUMI TAKAHARU (JP)
SUDOH MASAKI (JP)
SOGAWA RYO (JP)
MORITA TAKUYA (JP)
HADA TAKAHIKO (JP)
MUROGA YUMIKO (JP)
TAKENOUCHI OSAMI (JP)
FURUYA MONORU (JP)
ENDO NORIAKI (JP)
TARBY CHRISTINE M (US)
MOREE WILNA (US)
TEIG STEVEN L (US)
COMBICHEM INC (US)
SHIOTA TATSUKI (JP)
KATAOKA KEN ICHIRO (JP)
IMAI MINORU (JP)
TSUTSUMI TAKAHARU (JP)
SUDOH MASAKI (JP)
SOGAWA RYO (JP)
MORITA TAKUYA (JP)
HADA TAKAHIKO (JP)
MUROGA YUMIKO (JP)
TAKENOUCHI OSAMI (JP)
FURUYA MONORU (JP)
ENDO NORIAKI (JP)
TARBY CHRISTINE M (US)
MOREE WILNA (US)
TEIG STEVEN L (US)
International Classes:
A61K31/40; A61K31/4025; A61K31/404; A61K31/4184; A61K31/422; A61K31/427; A61K31/433; A61K31/4427; A61K31/443; A61K31/4433; A61K31/4439; A61K31/445; A61K31/4468; A61K31/4525; C07D223/02; A61K31/4535; A61K31/454; A61K31/4545; A61K31/55; A61P1/00; A61P1/04; A61P1/16; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P43/00; C07D207/09; C07D207/14; C07D207/325; C07D207/34; C07D207/416; C07D209/08; C07D209/42; C07D211/26; C07D211/56; C07D211/58; C07D213/65; C07D213/75; C07D213/81; C07D213/82; C07D231/14; C07D231/16; C07D235/16; C07D239/52; C07D249/18; C07D261/08; C07D263/56; C07D263/58; C07D271/06; C07D285/14; C07D307/14; C07D307/68; C07D317/50; C07D317/60; C07D319/18; C07D333/16; C07D333/20; C07D333/38; C07D333/42; C07D333/68; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D405/06; C07D405/12; C07D405/14; C07D407/12; C07D409/06; C07D409/12; C07D409/14; C07D413/06; C07D413/12; C07D413/14; C07D417/06; C07D417/12; C07D487/04; C07D495/04; C07D513/04; C07D207/32; C07D207/40; (IPC1-7): C07D211/58; A61K31/435; A61K31/41; C07D207/14; C07D211/56; C07D211/26; C07D207/09; C07D401/12; C07D405/12; C07D409/12; C07D413/06; C07D413/14; C07D409/06; C07D405/06
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