Title:
CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN (CBP) AND/OR ADENOVIRAL E1A BINDING PROTEIN OF 300 KDA (P300) DEGRADATION COMPOUNDS AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2022/042707
Kind Code:
A1
Abstract:
Provided are bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof, and methods for identifying such bivalent compounds.
Inventors:
LIU JING (US)
PLEWE MICHAEL BRUNO (US)
WANG JIALIANG (US)
HAN XIAORAN (CN)
CHEN LIQUN (CN)
ZHANG CHENGWEI (CN)
PLEWE MICHAEL BRUNO (US)
WANG JIALIANG (US)
HAN XIAORAN (CN)
CHEN LIQUN (CN)
ZHANG CHENGWEI (CN)
Application Number:
PCT/CN2021/115167
Publication Date:
March 03, 2022
Filing Date:
August 27, 2021
Export Citation:
Assignee:
CULLGEN SHANGHAI INC (CN)
International Classes:
A61K47/55; A61K31/4725; A61P35/00
Domestic Patent References:
| WO2020173440A1 | 2020-09-03 | |||
| WO2016086200A1 | 2016-06-02 | |||
| WO2017176958A1 | 2017-10-12 | |||
| WO2017185023A1 | 2017-10-26 | |||
| WO2020092907A1 | 2020-05-07 |
Other References:
VANNAM RAGHU; SAYILGAN JAN; OJEDA SAMUEL; KARAKYRIAKOU BARBARA; HU EILEEN; KREUZER JOHANNES; MORRIS ROBERT; HERRERA LOPEZ XCANDA I: "Targeted degradation of the enhancer lysine acetyltransferases CBP and p300", CELL CHEMICAL BIOLOGY , ELSEVIER, AMSTERDAM, NL, vol. 28, no. 4, 4 January 2021 (2021-01-04), AMSTERDAM, NL , pages 503, XP086538285, ISSN: 2451-9456, DOI: 10.1016/j.chembiol.2020.12.004
F. ANTHONY ROMERO, JEREMY MURRAY, KWONG WAH LAI, VICKIE TSUI, BRIAN K. ALBRECHT, LE AN, MAUREEN H. BERESINI, GLADYS DE LEON BOENIG: "GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 60, no. 22, 22 November 2017 (2017-11-22), US , pages 9162 - 9183, XP055472638, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b00796
BASSI ZUNI I., FILLMORE MARTIN C., MIAH AFJAL H., CHAPMAN TREVOR D., MALLER CLAIRE, ROBERTS EMMA J., DAVIS LAUREN C., LEWIS DARCY : "Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach", ACS CHEMICAL BIOLOGY, vol. 13, no. 10, 19 October 2018 (2018-10-19), pages 2862 - 2867, XP055903318, ISSN: 1554-8929, DOI: 10.1021/acschembio.8b00705
MARCEL SCHEEPSTRA, KOEN F.W. HEKKING, LUC VAN HIJFTE, RUTGER H.A. FOLMER: "Bivalent Ligands for Protein Degradation in Drug Discovery", COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, ELSEVIER, vol. 17, 1 January 2019 (2019-01-01), pages 160 - 176, XP055729199, DOI: 10.1016/j.csbj.2019.01.006
F. ANTHONY ROMERO, JEREMY MURRAY, KWONG WAH LAI, VICKIE TSUI, BRIAN K. ALBRECHT, LE AN, MAUREEN H. BERESINI, GLADYS DE LEON BOENIG: "GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 60, no. 22, 22 November 2017 (2017-11-22), US , pages 9162 - 9183, XP055472638, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b00796
BASSI ZUNI I., FILLMORE MARTIN C., MIAH AFJAL H., CHAPMAN TREVOR D., MALLER CLAIRE, ROBERTS EMMA J., DAVIS LAUREN C., LEWIS DARCY : "Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach", ACS CHEMICAL BIOLOGY, vol. 13, no. 10, 19 October 2018 (2018-10-19), pages 2862 - 2867, XP055903318, ISSN: 1554-8929, DOI: 10.1021/acschembio.8b00705
MARCEL SCHEEPSTRA, KOEN F.W. HEKKING, LUC VAN HIJFTE, RUTGER H.A. FOLMER: "Bivalent Ligands for Protein Degradation in Drug Discovery", COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, ELSEVIER, vol. 17, 1 January 2019 (2019-01-01), pages 160 - 176, XP055729199, DOI: 10.1016/j.csbj.2019.01.006
Attorney, Agent or Firm:
XU&PARTNERS, LLC. (CN)
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