Title:
CYCLIC ANALOG OF THYMUS PENTAPEPTIDE, ITS PREPARING METHOD AND USE
Document Type and Number:
WIPO Patent Application WO/2008/148247
Kind Code:
A1
Abstract:
An recombinant cyclic analog of thymus pentapeptide (TP5) and its preparing
method are disclosed. The structural formula of the TP5 analog is cyclo-(Cys-Arg-Lys-Asp-Val-Tyr-),
and the TP5 analog has better biological activity and stability, and can be used
for preparing immune diseases related medicines.
Inventors:
HAN WEIYUE (CN)
ZHANG RENHUAI (CN)
YANG LIMING (CN)
YANG YONG (CN)
LIU DELIN (CN)
LIN JIKAN (CN)
WEN YALEI (CN)
HE KAI (CN)
ZHANG RENHUAI (CN)
YANG LIMING (CN)
YANG YONG (CN)
LIU DELIN (CN)
LIN JIKAN (CN)
WEN YALEI (CN)
HE KAI (CN)
Application Number:
PCT/CN2007/001823
Publication Date:
December 11, 2008
Filing Date:
June 08, 2007
Export Citation:
Assignee:
GENE TECH PHARM GROUP DONG GUA (CN)
HAN WEIYUE (CN)
ZHANG RENHUAI (CN)
YANG LIMING (CN)
YANG YONG (CN)
LIU DELIN (CN)
LIN JIKAN (CN)
WEN YALEI (CN)
HE KAI (CN)
HAN WEIYUE (CN)
ZHANG RENHUAI (CN)
YANG LIMING (CN)
YANG YONG (CN)
LIU DELIN (CN)
LIN JIKAN (CN)
WEN YALEI (CN)
HE KAI (CN)
International Classes:
C07K7/64; A61K38/12; A61P37/00; C12N15/12; C12N15/63; C12P21/02
Foreign References:
| US4547489A | 1985-10-15 | |||
| CN1982331A | 2007-06-20 |
Other References:
YU R. ET AL.: "Preparation, characterization and bioactivity assay of a recombinant Tp-5 cyclic analogue cyclo(Cys-Arg-Lys-Asp-Val-Tyr)", CHINESE JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 22, no. 8, August 2006 (2006-08-01), pages 652 - 658
EVANS T.C. ET AL.: "The cyclization and polymerization of bacterially expressed proteins using modified self-splicing inteins", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 26, 1999, pages 18359 - 18363, XP002137480
EVANS T.C. ET AL.: "The cyclization and polymerization of bacterially expressed proteins using modified self-splicing inteins", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 26, 1999, pages 18359 - 18363, XP002137480
Attorney, Agent or Firm:
TEE & HOWE INTELLECTUAL PROPERTY ATTORNEY (Room 718 Beijing Capital Times Square, 88 Xichang'an Avenue, Xicheng District, Beijing 1, CN)
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