Title:
CYCLIC CELL PENETRATING PEPTIDES COMPRISING BETA-HAIRPIN MOTIFS AND METHODS OF MAKING AND USING THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/098282
Kind Code:
A3
Abstract:
Disclosed herein are peptides having activity as cell penetrating peptides. In some embodiments, the peptides can comprise a cell penetrating peptide moiety and beta-hairpin turn creating moiety. In other embodiments, the peptides also comprise a cargo moiety.
Inventors:
PEI DEHUA (US)
QIAN ZIQING (US)
QIAN ZIQING (US)
Application Number:
PCT/US2017/063020
Publication Date:
July 05, 2018
Filing Date:
November 22, 2017
Export Citation:
Assignee:
OHIO STATE INNOVATION FOUNDATION (US)
International Classes:
A61K38/03; A61K38/08; A61K38/10; A61K38/12; C07K7/64
Domestic Patent References:
| WO2015179691A2 | 2015-11-26 | |||
| WO2015051030A2 | 2015-04-09 |
Other References:
ZHAO, B ET AL.: "A Thioether-Stabilized d-Proline-I-Proline-Induced [Beta]-Hairpin Peptide of Defensin Segment Increases Its Anti-Candida albicans Ability", CHEMBIOCHEM: A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY, vol. 17, no. 15, 20 June 2016 (2016-06-20), pages 1416 - 1420, XP055510467
VRIENS, K ET AL.: "Antifungal Plant Defensins: Mechanisms of Action and Production.", MOLECULES, vol. 19, no. 8, 14 August 2013 (2013-08-14), pages 12280 - 12303, XP055181476
VRIENS, K ET AL.: "Antifungal Plant Defensins: Mechanisms of Action and Production.", MOLECULES, vol. 19, no. 8, 14 August 2013 (2013-08-14), pages 12280 - 12303, XP055181476
Attorney, Agent or Firm:
CURFMAN, Christopher L. et al. (US)
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