Title:
CYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2018/047888
Kind Code:
A1
Abstract:
The present invention provides a compound that has an exceptional TLR4 signal-inhibiting action and can be useful as a drug for the prevention or treatment of autoimmune diseases and/or inflammatory diseases or diseases such as chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver disorders, ischemic reperfusion injury (IRI), etc. The present invention pertains to ethyl 6-((2-chloro-4-fluorobenzyl)sulfonyl)-3-hydroxycyclohex-1-ene-1-carboxylate or optical isomers thereof.
Inventors:
KOBAYASHI TOSHITAKE (JP)
SAITOH MORIHISA (JP)
WADA YASUFUMI (JP)
NEGORO NOBUYUKI (JP)
YAMASAKI MASASHI (JP)
TANAKA TAKAHIRO (JP)
KITAMOTO NAOMI (JP)
SAITOH MORIHISA (JP)
WADA YASUFUMI (JP)
NEGORO NOBUYUKI (JP)
YAMASAKI MASASHI (JP)
TANAKA TAKAHIRO (JP)
KITAMOTO NAOMI (JP)
Application Number:
PCT/JP2017/032192
Publication Date:
March 15, 2018
Filing Date:
September 07, 2017
Export Citation:
Assignee:
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
C07C317/46; A61K31/235; A61P1/16; A61P9/10; A61P25/02; A61P29/00; A61P37/02; A61P43/00
Domestic Patent References:
| WO2007132825A1 | 2007-11-22 | |||
| WO2007123186A1 | 2007-11-01 | |||
| WO2003084527A1 | 2003-10-16 | |||
| WO2001010826A1 | 2001-02-15 |
Foreign References:
| JP2013518032A | 2013-05-20 |
Other References:
YAMADA, MASAMI ET AL.: "Novel cyclohexene derivatives as anti-sepsis agents: Synthetic studies and inhibition of NO and cytokine production", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, no. 7, 2008, pages 3941 - 3958, XP022593503, DOI: doi:10.1016/j.bmc.2008.01.030
See also references of EP 3511320A4
See also references of EP 3511320A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (JP)
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