Title:
CYCLIC COMPOUNDS AND MEDICINAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/1999/008991
Kind Code:
A1
Abstract:
Cyclic compounds represented by general formula (1) A^COOR?1¿, or pharmaceutically acceptable salts thereof, medicinal compositions containing these compounds, and remedies for diabetes containing these compounds wherein A represents, (a), (b), (c) or (d), wherein R?2¿ represents halogenated lower alkyl; R?3¿ represents halogeno or lower alkyl; R?4¿ represents lower alkyl; and R?5¿ represents lower alkyl; and R?1¿ represents hydrogen, lower alkyl, aryl, cycloalkyl or aralkyl. The compounds (1) or pharmaceutically acceptable salts thereof exert excellent hypoglycemic effects in a hyperglycemic state but do not affect blood sugar level in a normal or hypoglycemic state, i.e., showing no serious side effects such as hypoglycemia. Thus, they are useful as remedies for diabetes and preventives for chronic complications of diabetes.
Inventors:
SHINKAI HISASHI (JP)
OZEKI HIDEKAZU (JP)
OTA TAKESHI (JP)
OZEKI HIDEKAZU (JP)
OTA TAKESHI (JP)
Application Number:
PCT/JP1998/003542
Publication Date:
February 25, 1999
Filing Date:
August 07, 1998
Export Citation:
Assignee:
JAPAN TOBACCO INC (JP)
SHINKAI HISASHI (JP)
OZEKI HIDEKAZU (JP)
OTA TAKESHI (JP)
SHINKAI HISASHI (JP)
OZEKI HIDEKAZU (JP)
OTA TAKESHI (JP)
International Classes:
C07C69/716; C07C69/738; C07C233/58; C07C233/63; (IPC1-7): C07C59/88; A61K31/12; A61K31/165; C07C59/80; C07C233/61; C07C233/63
Foreign References:
| JPH09286755A | 1997-11-04 |
Other References:
SHIMADA J.-I., ET AL.: "RING EXPANSION AND CLEAVAGE OF SUCCINOIN DERIVATIVES. GEMINAL ACYLATION, REDUCTIVE SUCCINOYLATION, AND STEREOSELECTIVE SPIRO ANNELATION METHODS.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, US, vol. 106., no. 06., 1 January 1984 (1984-01-01), US, pages 1759 - 1773., XP002914508, ISSN: 0002-7863, DOI: 10.1021/ja00318a035
Attorney, Agent or Firm:
Takashima, Hajime (Hiranomachi 3-chome Chuo-ku Osaka-shi Osaka, JP)
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