Title:
CYCLIC-DI-AMP SODIUM SALT CRYSTAL
Document Type and Number:
WIPO Patent Application WO/2020/090948
Kind Code:
A1
Abstract:
A freeze-dried product of cyclic-di-AMP requires special production facilities and, therefore, is not suitable for large-scale production. A free acid crystal of cyclic-di-AMP is unstable under severe conditions at 105°C. Under these circumstances, the present invention addresses the problem of providing a cyclic-di-AMP crystal that can be easily acquired in a large amount and has a high stability under the severe conditions at 105°C. The c-di-AMP sodium salt crystal according to the present invention is extremely stable even under the severe conditions at 105°C. Further, the c-di-AMP sodium salt crystal according to the present invention can be prepared in a large amount by a simple method which comprises adjusting an aqueous c-di-AMP solution to pH 5.2-12.0 and then adding an organic solvent thereto.
Inventors:
TAKAMATSU MISAKI (JP)
YOSHIDA KO (JP)
MATSUNAGA MARIE (JP)
ISHIGE KAZUYA (JP)
YOSHIDA KO (JP)
MATSUNAGA MARIE (JP)
ISHIGE KAZUYA (JP)
Application Number:
PCT/JP2019/042706
Publication Date:
May 07, 2020
Filing Date:
October 31, 2019
Export Citation:
Assignee:
YAMASA CORP (JP)
International Classes:
C07H1/06; C07H21/02
Domestic Patent References:
| WO2015137469A1 | 2015-09-17 | |||
| WO2015137469A1 | 2015-09-17 |
Foreign References:
| JP2003519698A | 2003-06-24 |
Other References:
AWAGUCHI, YOKO; KONNO, MICHIKO; AIKAWA, YOSHIHIRO: "Drug and crystal polymorphism", JOURNAL OF HUMAN ENVIRONMENTAL ENGINEERING, vol. 4, no. 2, 30 November 2001 (2001-11-30), JP, pages 310 - 317, XP009527798
ANONYMOUS: "3.3.1. New Pharmaceuticals", PHARMACEUTICAL INVESTIGATION , vol. 568, 2001, JP, pages 1 - 46, XP009527831
HIROSHI OSHIMA : "Kessho Takei-Gitakei no Sekishutsu Kyodo to Seigyo - Crystallization of Polymorphs and Pseudo-polymorphs and Its Control", PHARM STAGE , vol. 6, no. 10, 1 January 2007 (2007-01-01), JP, pages 48 - 53, XP008184800, ISSN: 1346-3918
NORIYUKI TAKADA : "Soyaku Dankai ni Okeru Gen'yaku Form Screening to Sentaku - API form screening and selection in drug discovery stage", PHARM STAGE , vol. 6, no. 10, 1 January 2007 (2007-01-01), JP, pages 20 - 25, XP008145548, ISSN: 1346-3918
MITSUHISA YAMANO: "Approach to Crystal Polymorph in Process Research of New Drug", JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN, vol. 65, no. 9, 1 September 2007 (2007-09-01), pages 907 - 913, XP055358201, ISSN: 0037-9980, DOI: 10.5059/yukigoseikyokaishi.65.907
STEPHEN BYRN, RALPH PFEIFFER, MICHAEL GANEY, CHARLES HOIBERG,GUIRAG POOCHIKIAN : "Pharmaceutical Solids: A Strategic Approach to Regulatory Considerations", PHARMACEUTICAL RESEARCH , vol. 12, no. 7, 1 July 1995 (1995-07-01), pages 945 - 954, XP055531015, DOI: 10.1023/A:1016241927429
SCIENCE, vol. 328, 2010, pages 1703 - 1705
SYNTHESIS, vol. 24, 2006, pages 4230 - 4236
NUCLEOSIDES NUCLEOTIDES NUCLEIC ACIDS, vol. 32, 2013, pages 1 - 16
MOLECULAR CELL, vol. 30, 2008, pages 167 - 178
NAGOYA J., MED. SCI., vol. 73, 2011, pages 49 - 57
See also references of EP 3875463A4
ANONYMOUS: "3.3.1. New Pharmaceuticals", PHARMACEUTICAL INVESTIGATION , vol. 568, 2001, JP, pages 1 - 46, XP009527831
HIROSHI OSHIMA : "Kessho Takei-Gitakei no Sekishutsu Kyodo to Seigyo - Crystallization of Polymorphs and Pseudo-polymorphs and Its Control", PHARM STAGE , vol. 6, no. 10, 1 January 2007 (2007-01-01), JP, pages 48 - 53, XP008184800, ISSN: 1346-3918
NORIYUKI TAKADA : "Soyaku Dankai ni Okeru Gen'yaku Form Screening to Sentaku - API form screening and selection in drug discovery stage", PHARM STAGE , vol. 6, no. 10, 1 January 2007 (2007-01-01), JP, pages 20 - 25, XP008145548, ISSN: 1346-3918
MITSUHISA YAMANO: "Approach to Crystal Polymorph in Process Research of New Drug", JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN, vol. 65, no. 9, 1 September 2007 (2007-09-01), pages 907 - 913, XP055358201, ISSN: 0037-9980, DOI: 10.5059/yukigoseikyokaishi.65.907
STEPHEN BYRN, RALPH PFEIFFER, MICHAEL GANEY, CHARLES HOIBERG,GUIRAG POOCHIKIAN : "Pharmaceutical Solids: A Strategic Approach to Regulatory Considerations", PHARMACEUTICAL RESEARCH , vol. 12, no. 7, 1 July 1995 (1995-07-01), pages 945 - 954, XP055531015, DOI: 10.1023/A:1016241927429
SCIENCE, vol. 328, 2010, pages 1703 - 1705
SYNTHESIS, vol. 24, 2006, pages 4230 - 4236
NUCLEOSIDES NUCLEOTIDES NUCLEIC ACIDS, vol. 32, 2013, pages 1 - 16
MOLECULAR CELL, vol. 30, 2008, pages 167 - 178
NAGOYA J., MED. SCI., vol. 73, 2011, pages 49 - 57
See also references of EP 3875463A4
Download PDF: