Title:
CYCLIC NUCLEOTIDE PHOSPHODIESTERASE INHIBITORS, PREPARATION AND USES
Document Type and Number:
WIPO Patent Application WO2004041258
Kind Code:
A3
Abstract:
The invention concerns the use of PDE2 inhibitors for treating disorders of the central and peripheral nervous system, a method for therapeutic treatment by administering to an animal said inhibitors. More specifically, the invention concerns novel benzodiazepinone derivatives and their uses in therapeutics more particularly for treating pathologies involving activity of type 2 cyclic nucleotide phosphodiesterase. The invention also concerns methods for preparing same and novel synthesis intermediates.
Inventors:
BOURGUIGNON JEAN-JACQUES (FR)
LUGNIER CLAIRE (FR)
ABARGHAZ MUSTAPHA (FR)
LAGOUGE YAN (FR)
WAGNER PATRICK (FR)
MONDADORI CESARE (CH)
MACHER JEAN-PAUL (FR)
SCHULTZ DOMINIQUE (FR)
RABOISSON PIERRE (US)
LUGNIER CLAIRE (FR)
ABARGHAZ MUSTAPHA (FR)
LAGOUGE YAN (FR)
WAGNER PATRICK (FR)
MONDADORI CESARE (CH)
MACHER JEAN-PAUL (FR)
SCHULTZ DOMINIQUE (FR)
RABOISSON PIERRE (US)
Application Number:
PCT/FR2003/003247
Publication Date:
September 23, 2004
Filing Date:
October 30, 2003
Export Citation:
Assignee:
NEURO3D (FR)
UNIV PASTEUR (FR)
CENTRE NAT RECH SCIENT (FR)
FORENAP (FR)
BOURGUIGNON JEAN-JACQUES (FR)
LUGNIER CLAIRE (FR)
ABARGHAZ MUSTAPHA (FR)
LAGOUGE YAN (FR)
WAGNER PATRICK (FR)
MONDADORI CESARE (CH)
MACHER JEAN-PAUL (FR)
SCHULTZ DOMINIQUE (FR)
RABOISSON PIERRE (US)
UNIV PASTEUR (FR)
CENTRE NAT RECH SCIENT (FR)
FORENAP (FR)
BOURGUIGNON JEAN-JACQUES (FR)
LUGNIER CLAIRE (FR)
ABARGHAZ MUSTAPHA (FR)
LAGOUGE YAN (FR)
WAGNER PATRICK (FR)
MONDADORI CESARE (CH)
MACHER JEAN-PAUL (FR)
SCHULTZ DOMINIQUE (FR)
RABOISSON PIERRE (US)
International Classes:
A61K31/5513; A61K31/5517; A61P3/04; A61P11/06; A61P19/02; A61P21/00; A61P25/08; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P37/00; C07D243/20; C07D243/22; C07D243/24; C07D401/04; C07D405/04; C07D417/10; C07D487/04; (IPC1-7): A61K31/5513; A61K31/5517; A61P25/08; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P11/06; A61P21/00; A61P19/02; A61P3/04; A61P37/00; A61P25/20
Domestic Patent References:
| WO1999058117A1 | 1999-11-18 | |||
| WO2002098865A2 | 2002-12-12 |
Foreign References:
| GB1346176A | 1974-02-06 | |||
| US3573282A | 1971-03-30 | |||
| US3803129A | 1974-04-09 | |||
| US4056525A | 1977-11-01 | |||
| DE1136709B | 1962-09-20 | |||
| DE1145626B | 1963-03-21 | |||
| US5010076A | 1991-04-23 | |||
| DE1942744A1 | 1971-03-04 | |||
| US3515755A | 1970-06-02 | |||
| US3723433A | 1973-03-27 | |||
| US3609146A | 1971-09-28 |
Other References:
PARFITT, K.: "Martindale. The Complete Drug Reference", 1999, PHARNMACEUTICAL PRESS, LONDON, UK., XP002245529
FRYER, R.I., ET AL.: "Quinazolines and 1,4-Benzodiazepins. XLV. 1,4-Benzodiazepines from 4-Isoquinolones.", J. ORG. CHEM, vol. 35, no. 7, 1970, pages 2455 - 249, XP001149447
KOLBACH, G., ET AL.: "Stereoselective in vitro aromatic-ring oxygenations of chiral 1,4-benzodiazepin-2-ones.", HELVETICA CHIMICA ACTA, vol. 60, no. 1, 1977, pages 265 - 283, XP001149178
STERNBACH, L.H., ET AL.: "Quinazolines and 1,4-Benzodiazepines. VI. Halo-, Methyl-, and Methoxy-substituted 1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-ones.", J. ORG. CHEM., vol. 27, 1962, pages 3788 - 3796, XP001149445
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; NAKAI, HIDEO ET AL: "1,4-Benzodiazepines", XP002245530, retrieved from STN Database accession no. 72:79116 HCA
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; HASEGAWA, HITOSHI: "1,4-Benzodiazepine series compounds", XP002245531, retrieved from STN Database accession no. 74:53864 HCA
DATABASE WPI Section Ch Week 198004, Derwent World Patents Index; Class B02, AN 1980-06578C, XP002245532
FRYER, R.I., ET AL.: "Quinazolines and 1,4-Benzodiazepins. XLV. 1,4-Benzodiazepines from 4-Isoquinolones.", J. ORG. CHEM, vol. 35, no. 7, 1970, pages 2455 - 249, XP001149447
KOLBACH, G., ET AL.: "Stereoselective in vitro aromatic-ring oxygenations of chiral 1,4-benzodiazepin-2-ones.", HELVETICA CHIMICA ACTA, vol. 60, no. 1, 1977, pages 265 - 283, XP001149178
STERNBACH, L.H., ET AL.: "Quinazolines and 1,4-Benzodiazepines. VI. Halo-, Methyl-, and Methoxy-substituted 1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-ones.", J. ORG. CHEM., vol. 27, 1962, pages 3788 - 3796, XP001149445
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; NAKAI, HIDEO ET AL: "1,4-Benzodiazepines", XP002245530, retrieved from STN Database accession no. 72:79116 HCA
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; HASEGAWA, HITOSHI: "1,4-Benzodiazepine series compounds", XP002245531, retrieved from STN Database accession no. 74:53864 HCA
DATABASE WPI Section Ch Week 198004, Derwent World Patents Index; Class B02, AN 1980-06578C, XP002245532
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