Title:
CYCLIC PEPTIDE, AFFINITY CHROMATOGRAPHY CARRIER, LABELED ANTIBODY, ANTIBODY-DRUG CONJUGATE, AND PHARMACEUTICAL PREPARATION
Document Type and Number:
WIPO Patent Application WO/2018/061509
Kind Code:
A1
Abstract:
Provided is a cyclic peptide having excellent antibody binding properties and improved chemical resistance. The cyclic peptide is represented by formula (I) below. (I) RN-Xg-[Xi-Xa-Xm-X1-X2-X3-Xn-Xb-Xj]k-Xh-RC. In formula (I), RN represents an N-terminal group; RC represents a C-terminal group; X1 represents an L-leucine residue, L-isoleucine residue, L-methionine residue, L-lysine residue, or L-arginine residue; X2 represents an L-valine residue or L-isoleucine residue; X3 represents an L-tryptophan residue or L-phenylalanine residue; one among Xa and Xb represents an amino acid residue derived from an amino acid having an azide group in a side chain, the other represents an amino acid residue derived from an amino acid having an alkynyl group in a side chain, and Xa and Xb are bonded via a triazole bond; Xg, Xh, Xi, Xj, Xm, and Xn respectively represent contiguous g X's, contiguous h X's, contiguous i X's, contiguous j X's, contiguous m X's, and contiguous n X's; X represents an amino acid residue, and when there are a plurality of X's, the plurality of X's may be the same or different; g, h, i, and j are each independently an integer of 0 or greater; m and n are integers satisfying 0≤m≤9, 0≤n≤9, and 3≤m+n≤9; and k is an integer of 1 or greater, and when k≥2, each of X1, X2, X3, Xa, Xb, Xi, Xj, Xm, and Xn may be the same or different for each of the repeating units [Xi-Xa-Xm-X1-X2-X3-Xn-Xb-Xj].
More Like This:
| WO/2012/162679 | PHOENIXIN PEPTIDES |
| JPH1023863 | NEW PEPTIDE COMPOSITION AND ITS PRODUCTION |
| WO/1991/006562 | IMMUNOLOGICAL DOMAINS OF HEPATITIS DELTA VIRUS ANTIGEN |
Inventors:
MINAMI KOICHI (JP)
Application Number:
PCT/JP2017/029517
Publication Date:
April 05, 2018
Filing Date:
August 17, 2017
Export Citation:
Assignee:
FUJIFILM CORP (JP)
International Classes:
C07K7/00; A61K39/395; A61K47/65; A61K47/68; C07K1/22; C07K16/00
Domestic Patent References:
| WO2013027796A1 | 2013-02-28 | |||
| WO2013027796A1 | 2013-02-28 | |||
| WO2016186206A1 | 2016-11-24 |
Foreign References:
| JP2015509486A | 2015-03-30 | |||
| US20040087765A1 | 2004-05-06 | |||
| JP2017095443A | 2017-06-01 | |||
| US20040087765A1 | 2004-05-06 | |||
| JP2007289200A | 2007-11-08 |
Other References:
KANG, H. J. ET AL.: "Cyclic peptide ligand with high binding capacity for affinity purification of immunoglobulin G", JOURNAL OF CHROMATOGRAPHY A, vol. 1466, 3 September 2016 (2016-09-03), pages 105 - 112, XP029732636, DOI: doi:10.1016/j.chroma.2016.09.007
GONG, Y. ET AL.: "Development of the double cyclic peptide ligand for antibody purification and protein detection", BIOCONJUGATE CHEMISTRY, vol. 27, no. 7, 30 June 2016 (2016-06-30), pages 1569 - 1573, XP055582578, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.6b00170
See also references of EP 3521300A4
GONG, Y. ET AL.: "Development of the double cyclic peptide ligand for antibody purification and protein detection", BIOCONJUGATE CHEMISTRY, vol. 27, no. 7, 30 June 2016 (2016-06-30), pages 1569 - 1573, XP055582578, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.6b00170
See also references of EP 3521300A4
Attorney, Agent or Firm:
NAKASHIMA Junko et al. (JP)
Download PDF: