Title:
CYCLIC PEPTIDE ANTIBIOTICS
Document Type and Number:
WIPO Patent Application WO/2019/052545
Kind Code:
A1
Abstract:
Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
Inventors:
HANAN EMILY J (US)
CASTANEDO GEORGETTE (US)
BRAUN MARIE GABRIELLE (US)
GARLAND KEIRA (US)
SMITH PETER ANDREW (US)
PASTOR RICHARD (US)
GIBBONS PAUL (US)
YUEN PO-WAI (CN)
CHENG YUNXING (CN)
WU GUOSHENG (CN)
FU YUHONG (CN)
CASTANEDO GEORGETTE (US)
BRAUN MARIE GABRIELLE (US)
GARLAND KEIRA (US)
SMITH PETER ANDREW (US)
PASTOR RICHARD (US)
GIBBONS PAUL (US)
YUEN PO-WAI (CN)
CHENG YUNXING (CN)
WU GUOSHENG (CN)
FU YUHONG (CN)
Application Number:
PCT/CN2018/105821
Publication Date:
March 21, 2019
Filing Date:
September 14, 2018
Export Citation:
Assignee:
HOFFMANN LA ROCHE (CH)
GENENTECH INC (US)
GENENTECH INC (US)
International Classes:
C07D273/00; A61P31/00
Foreign References:
| JPS5547644A | 1980-04-04 | |||
| JPS53141202A | 1978-12-08 | |||
| US5384309A | 1995-01-24 |
Other References:
KIHO T. ET AL.: "Synthesis and Antimicrobial Activity of Novel Globomycin Analogues", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 14, 31 December 2003 (2003-12-31), pages 2315 - 2318, XP055582774
KIHO T. ET AL.: "Total synthesis and NMR conformational study of signal peptidase II inhibitors, globomycin and SF-1902 A5", TETRAHEDRON, vol. 59, no. 10, 31 December 2003 (2003-12-31), pages 1685 - 1697, XP004410943, DOI: doi:10.1016/S0040-4020(03)00110-8
SARABIA F. ET AL.: "Solid Phase Synthesis of Globomycin and SF-1902 A5", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 76, no. 7, 2 March 2011 (2011-03-02), pages 2132 - 2144, XP055582775
"Fieser and Fieser's Reagents for Organic Synthesis", vol. 1, 1991, JOHN WILEY AND SONS
"Larock's Comprehensive Organic Transformations", vol. 1, 1989, ELSEVIER SCIENCE PUBLISHERS
HETEROCYCLES, vol. 86, 2012, pages 735 - 743
See also references of EP 3681875A4
KIHO T. ET AL.: "Total synthesis and NMR conformational study of signal peptidase II inhibitors, globomycin and SF-1902 A5", TETRAHEDRON, vol. 59, no. 10, 31 December 2003 (2003-12-31), pages 1685 - 1697, XP004410943, DOI: doi:10.1016/S0040-4020(03)00110-8
SARABIA F. ET AL.: "Solid Phase Synthesis of Globomycin and SF-1902 A5", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 76, no. 7, 2 March 2011 (2011-03-02), pages 2132 - 2144, XP055582775
"Fieser and Fieser's Reagents for Organic Synthesis", vol. 1, 1991, JOHN WILEY AND SONS
"Larock's Comprehensive Organic Transformations", vol. 1, 1989, ELSEVIER SCIENCE PUBLISHERS
HETEROCYCLES, vol. 86, 2012, pages 735 - 743
See also references of EP 3681875A4
Attorney, Agent or Firm:
AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (CN)
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