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Title:
CYCLIC PEPTIDE COMPOUND HAVING HIGH MEMBRANE PERMEABILITY, AND LIBRARY CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2018/225864
Kind Code:
A1
Abstract:
The present inventors found that, in screening a cyclic peptide compound capable of specifically binding to a target molecule, the hitting rate of a cyclic peptide compound capable of specifically binding to the target molecule can be improved by using a library which contains cyclic peptide compounds having a long side chain in the cyclic moiety. Meanwhile, the present inventors found that indole skeletons, which are employed in conventional low molecular drugs for oral use, and tryptophan and tyrosine residues, which are amino acid residues having a hydroxyphenyl group, are unsuitable for a peptide aiming at a high membrane permeability.

Inventors:
MURAOKA TERUSHIGE (JP)
IIDA TAKEO (JP)
MATSUO ATSUSHI (JP)
TAKEYAMA RYUICHI (JP)
TANADA MIKIMASA (JP)
TANAKA SHOTA (JP)
HAYASHI RYUJI (JP)
FUJINO MACHIKO (JP)
IIKURA HITOSHI (JP)
Application Number:
JP2018/022097
Publication Date:
December 13, 2018
Filing Date:
June 08, 2018
Export Citation:
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Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C40B40/10; C07K1/13; C07K2/00; C12P21/02; C40B30/04; G01N33/566; C07K7/64; C12N15/09
Domestic Patent References:
WO2013100132A12013-07-04
WO2017136708A12017-08-10
WO2013100132A12013-07-04
WO2012033154A12012-03-15
WO2016148044A12016-09-22
WO2008117833A12008-10-02
WO2012074129A12012-06-07
WO2013100132A12013-07-04
Foreign References:
JP2017043615A2017-03-02
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Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
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