Title:
CYCLIC PEPTIDE HAVING VIRUS PROLIFERATION INHIBITION ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2023/048151
Kind Code:
A1
Abstract:
The present invention provides a compound having a corona virus proliferation inhibition activity, and/or a pharmaceutical composition containing the compound having a corona virus proliferation inhibition activity. A compound represented by (I) (in the formula, R1 represents a hydrogen atom or the like, R2 represents a group or the like represented by formula: -(CR2aR2b)t2-Y2, R2' represents a hydrogen atom or the like, R3 represents a hydrogen atom or the like, R4 represents a substituted or unsubstituted alkyl, R4' represents a hydrogen atom, R5 represents a hydrogen atom, R6 represents a group or the like represented by formula: -(CR6aR6b)t6-Y6, R6' represents a hydrogen atom or the like, R7 represents a hydrogen atom or the like, R8 represents a group represented by formula: -(CR8aR8b)t8-Y8, R8' represents a hydrogen atom, R9 represents a hydrogen atom or the like, R10 represents a substituted or unsubstituted alkyl or the like, R10' represents a hydrogen atom or the like, R11 represents a hydrogen atom or the like, R12 represents a group or the like represented by formula: -(CR12aR12b)t12-Y12, R12' represents a hydrogen atom or the like, R13 represents a substituted or unsubstituted alkyl, R13' represents a hydrogen atom, R14 represents a hydrogen atom, R15 represents a substituted or unsubstituted alkyl or the like, R15' represents a hydrogen atom or the like, R16 represents a hydrogen atom, R17 represents a group represented by formula: -(CR17aR17b)t17-Y17, R17' represents a hydrogen atom, R18 represents a hydrogen atom, R19 represents a substituted or unsubstituted alkyl, R19' represents a hydrogen atom or the like, R20 represents a hydrogen atom, R21 represents a group or the like represented by formula: -(CR21aR21b)t21-Y21, R21' represents a hydrogen atom, R22 represents a hydrogen atom or the like, -L- represents -S- or the like, and X represents a lipid-modifying residue), or a pharmaceutically acceptable salt thereof.
Inventors:
KAWAGUCHI YOSHIMASA (JP)
UEDA TAICHI (JP)
YAMADA TORU (JP)
KUSUMOTO YOSHIFUMI (JP)
SANO MASAYUKI (JP)
SANAKI TAKAO (JP)
TOBA SHINSUKE (JP)
SASAKI MICHIHITO (JP)
UEDA TAICHI (JP)
YAMADA TORU (JP)
KUSUMOTO YOSHIFUMI (JP)
SANO MASAYUKI (JP)
SANAKI TAKAO (JP)
TOBA SHINSUKE (JP)
SASAKI MICHIHITO (JP)
Application Number:
PCT/JP2022/035043
Publication Date:
March 30, 2023
Filing Date:
September 21, 2022
Export Citation:
Assignee:
SHIONOGI & CO (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
C07K7/08; A61K9/72; A61K38/12; A61P31/14; C07K19/00
Domestic Patent References:
| WO2021048646A1 | 2021-03-18 | |||
| WO2021037942A1 | 2021-03-04 | |||
| WO2022202816A1 | 2022-09-29 |
Foreign References:
| CN112646001A | 2021-04-13 | |||
| CN111499692A | 2020-08-07 | |||
| CN111518163A | 2020-08-11 | |||
| JP2012525443A | 2012-10-22 |
Attorney, Agent or Firm:
SUGITA Ken-ichi et al. (JP)
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