Title:
CYCLIC SULFONIUM SALT, PROCESS FOR PRODUCTION OF SAME, AND α-GLUCOSIDASE INHIBITOR COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2012/105573
Kind Code:
A1
Abstract:
Provided is a novel cyclic sulfonium salt compound which is useful for the prevention or treatment of diabetes and the like. The present invention relates to a novel cyclic sulfonium salt compound represented by general formula (I) or (II), an isomer or solvate of the compound, or a pharmaceutically acceptable salt of the compound or the isomer or solvate. The present invention also relates to an α-glucosidase inhibitor, a pharmaceutical composition for preventing or treating diabetes, and an anti-diabetes food, each of which comprises the compound represented by general formula (I) or (II) and the like.
Inventors:
MURAOKA OSAMU (JP)
TANABE GENZOH (JP)
TANABE GENZOH (JP)
Application Number:
PCT/JP2012/052174
Publication Date:
August 09, 2012
Filing Date:
January 31, 2012
Export Citation:
Assignee:
UNIV KINKI (JP)
DIABETYM CO LTD (JP)
MURAOKA OSAMU (JP)
TANABE GENZOH (JP)
DIABETYM CO LTD (JP)
MURAOKA OSAMU (JP)
TANABE GENZOH (JP)
International Classes:
A23L1/30; C07D333/46; A61K31/381; A61P3/04; A61P3/06; A61P3/10; A61P9/12; A61P13/12; A61P25/00; A61P27/02; A61P27/12; A61P43/00
Domestic Patent References:
| WO2004113289A2 | 2004-12-29 |
Foreign References:
| JP2002179673A | 2002-06-26 | |||
| JP2004323420A | 2004-11-18 | |||
| JP2005002051A | 2005-01-06 |
Other References:
ESKANDARI,R. ET AL.: "Probing the active-site requirements of human intestinal N-terminal maltase glucoamylase: The effect of replacing the sulfate moiety by a methyl ether in ponkoranol, a naturally occurring a-glucosidase inhibitor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, no. 19, 2010, pages 5686 - 5689, XP027273540
ESKANDARI,R. ET AL.: "Selectivity of 3'-0- methylponkoranol for inhibition of N- and C-terminal maltase glucoamylase and sucrase isomaltase, potential therapeutics for digestive disorders or their sequelae", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, no. 21, 1 November 2011 (2011-11-01), pages 6491 - 6494, XP028308802
TANABE,G. ET AL.: "Biological evaluation of 3'-O-alkylated analogs of salacinol, the role of hydrophobic alkyl group at 3' position in the side chain on the a-glucosidase inhibitory activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, no. 10, 15 May 2011 (2011-05-15), pages 3159 - 3162, XP028208800
YOSHIKAWA, M.; MURAOKA, 0. ET AL., TETRAHEDRON LETT., vol. 38, 1997, pages 8367
YOSHIKAWA, M.; MURAOKA, 0. ET AL., BIOORG. MED. CHEM., vol. 10, 2002, pages 1547
YOSHIKAWA, M. ET AL., CHEM. PHARM. BULL., vol. 46, 1998, pages 1339
YOSHIKAWA, M.; MURAOKA, 0., HETEROCYCLES, vol. 75, 2008, pages 1397
ESKANDARI, R. ET AL., BIOORG. MED. CHEM. LETT., vol. 20, 2010, pages 5686
ABUSHANAB E.; VEMISHETTI P.; LEIBY R. W.; SINGH H. K.; MIKKILINENI A. B.; WU D. C.-J.; SAIBABA R.; PANZICA, R. P., J. ORG. CHEM., vol. 53, 1988, pages 2598
See also references of EP 2671879A4
ESKANDARI,R. ET AL.: "Selectivity of 3'-0- methylponkoranol for inhibition of N- and C-terminal maltase glucoamylase and sucrase isomaltase, potential therapeutics for digestive disorders or their sequelae", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, no. 21, 1 November 2011 (2011-11-01), pages 6491 - 6494, XP028308802
TANABE,G. ET AL.: "Biological evaluation of 3'-O-alkylated analogs of salacinol, the role of hydrophobic alkyl group at 3' position in the side chain on the a-glucosidase inhibitory activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, no. 10, 15 May 2011 (2011-05-15), pages 3159 - 3162, XP028208800
YOSHIKAWA, M.; MURAOKA, 0. ET AL., TETRAHEDRON LETT., vol. 38, 1997, pages 8367
YOSHIKAWA, M.; MURAOKA, 0. ET AL., BIOORG. MED. CHEM., vol. 10, 2002, pages 1547
YOSHIKAWA, M. ET AL., CHEM. PHARM. BULL., vol. 46, 1998, pages 1339
YOSHIKAWA, M.; MURAOKA, 0., HETEROCYCLES, vol. 75, 2008, pages 1397
ESKANDARI, R. ET AL., BIOORG. MED. CHEM. LETT., vol. 20, 2010, pages 5686
ABUSHANAB E.; VEMISHETTI P.; LEIBY R. W.; SINGH H. K.; MIKKILINENI A. B.; WU D. C.-J.; SAIBABA R.; PANZICA, R. P., J. ORG. CHEM., vol. 53, 1988, pages 2598
See also references of EP 2671879A4
Attorney, Agent or Firm:
MATSUO KENICHIRO (JP)
Ken-ichiro Matsuo (JP)
Ken-ichiro Matsuo (JP)
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