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Title:
A CYCLIN-DEPENDENT KINASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2023/040998
Kind Code:
A1
Abstract:
Provided herein are a series of compounds as potent inhibitors of cyclin-dependent kinase (CDK), or pharmaceutically acceptable salts thereof. Corresponding compositions are also provided.

Inventors:
MO LEI (CN)
HUANG JUNKAI (CN)
LI KAI (CN)
QIAO JIAN (CN)
YUAN TINGYU (CN)
XIE YONGPING (CN)
HU XIAOHUI (CN)
ZHOU LI (CN)
CUI TAO (CN)
CHEN DONGQIANG (CN)
TANG SIWEN (CN)
YAO YAO (CN)
LI HETING (CN)
HEGDE DEEPAK (CN)
ZOU XIAOMING (CN)
Application Number:
PCT/CN2022/119183
Publication Date:
March 23, 2023
Filing Date:
September 16, 2022
Export Citation:
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Assignee:
TAIZHOU EOC PHARMA CO LTD (CN)
International Classes:
C07D403/14; A61K31/475; A61K31/55; A61K31/7064; A61P35/00; C07D223/02
Domestic Patent References:
WO2022134642A12022-06-30
WO2022063212A12022-03-31
WO2019143730A12019-07-25
WO2011133388A12011-10-27
WO2020093006A12020-05-07
WO2019143719A12019-07-25
WO2017094026A12017-06-08
Foreign References:
CN114907407A2022-08-16
CN112661745A2021-04-16
Other References:
JIANG BAISHAN, JIANG JIE, KALTHEUNER INES H., INIGUEZ AMANDA BALBONI, ANAND KANCHAN, FERGUSON FLEUR M., FICARRO SCOTT B., SEONG BO: "Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 221, 1 October 2021 (2021-10-01), AMSTERDAM, NL , pages 113481, XP093048367, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2021.113481
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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