Title:
CYCLOALKYLAMINE DERIVATIVES AS NK-1 /SSRI ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO2006023187
Kind Code:
A3
Abstract:
The present disclosure relates to chemical compounds and their use in human therapy. A specific embodiment relates to compounds of Formula (I) or an isomer, a pharmaceutically acceptable salt or solvate thereof and pharmaceutically acceptable formulations comprising said compounds Formula (I); useful for the treatment or prevention of conditions mediated by tachykinins and/or selective inhibition of serotonin reuptake transporter protein. The compounds act as dual NK-1 antagonists and selective serotonin reuptake inhibitors.
Inventors:
WU YONG-JIN (US)
HE HUAN (US)
HE HUAN (US)
Application Number:
PCT/US2005/025635
Publication Date:
August 31, 2006
Filing Date:
July 20, 2005
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB CO (US)
WU YONG-JIN (US)
HE HUAN (US)
WU YONG-JIN (US)
HE HUAN (US)
International Classes:
C07D223/00
Domestic Patent References:
| WO2004056771A1 | 2004-07-08 | |||
| WO2004022539A1 | 2004-03-18 | |||
| WO1999062900A1 | 1999-12-09 |
Other References:
STEVENSON G.I. ET AL.: "4,4-Disubstituted Piperidine High-Affinity NK1 Antagonists: Structure-Activity Relationships and in Vivo Activity", J. MED. CHEM., vol. 41, no. 23, June 1998 (1998-06-01), pages 4623 - 4635, XP002205489
STEVENSON G.I. ET AL.: "4,4-Disubstituted Piperidine: A New Class of NK1 Antagonist", J. MED. CHEM., vol. 38, no. 8, 1995, pages 1264 - 1266, XP002974380
STEVENSON G.I. ET AL.: "4,4-Disubstituted Piperidine: A New Class of NK1 Antagonist", J. MED. CHEM., vol. 38, no. 8, 1995, pages 1264 - 1266, XP002974380
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