Title:
CYCLOASTRAGENOL MONOGLUCOSIDE, PREPARATION, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2009/046620
Kind Code:
A1
Abstract:
Provided is a method of preparing cycloastragenol monoglycoside CMG (cycloastragenol-6-O-beta-D-glucoside),
which comprises the following steps of: a. using astragaloside IV or extracts
of Radix Astragali by conventional method as material and adding a proper solvent
to prepare medical solution; b. adding hydrolase and hydrolyzing at constant
temperature to get hydrolysate; c. separating hydrolysate with macroporous
adsorption resin; and d. obtaining products by purification and separation.
Cycloastragenol-6-O-beta-D-glucoside by the method and its use for producing
medicine for treating cardiovascular diseases, pharmaceutical composition
comprising it are also provided.
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Inventors:
HAN YINGMEI (CN)
XIA GUANGPING (CN)
XU WEIREN (CN)
ZHAO ZHUANYOU (CN)
LIU WULIN (CN)
ZHAO NAXIA (CN)
LIU PENG (CN)
ZHANG SHIJUN (CN)
WANG YULI (CN)
WANG WEITING (CN)
TANG LIDA (CN)
XIA GUANGPING (CN)
XU WEIREN (CN)
ZHAO ZHUANYOU (CN)
LIU WULIN (CN)
ZHAO NAXIA (CN)
LIU PENG (CN)
ZHANG SHIJUN (CN)
WANG YULI (CN)
WANG WEITING (CN)
TANG LIDA (CN)
Application Number:
PCT/CN2008/001594
Publication Date:
April 16, 2009
Filing Date:
September 08, 2008
Export Citation:
Assignee:
TIANJIN INST PHARM RESEARCH (CN)
FU XIAOLI (CN)
HAN YINGMEI (CN)
XIA GUANGPING (CN)
XU WEIREN (CN)
ZHAO ZHUANYOU (CN)
LIU WULIN (CN)
ZHAO NAXIA (CN)
LIU PENG (CN)
ZHANG SHIJUN (CN)
WANG YULI (CN)
WANG WEITING (CN)
TANG LIDA (CN)
FU XIAOLI (CN)
HAN YINGMEI (CN)
XIA GUANGPING (CN)
XU WEIREN (CN)
ZHAO ZHUANYOU (CN)
LIU WULIN (CN)
ZHAO NAXIA (CN)
LIU PENG (CN)
ZHANG SHIJUN (CN)
WANG YULI (CN)
WANG WEITING (CN)
TANG LIDA (CN)
International Classes:
C12P19/56; A61K9/00; A61K9/08; A61K9/12; A61K9/19; A61K31/7048; A61P9/00; C07H17/04; A61K36/481
Domestic Patent References:
| WO2005000248A2 | 2005-01-06 |
Foreign References:
| CN1544458A | 2004-11-10 | |||
| CN1569884A | 2005-01-26 | |||
| CN1809364A | 2006-07-26 | |||
| CN1793132A | 2006-06-28 | |||
| CN1919203A | 2007-02-28 | |||
| CN1669566A | 2005-09-21 | |||
| CN1854148A | 2006-11-01 | |||
| CN1172677C | 2004-10-27 | |||
| CN1543976A | 2004-11-10 | |||
| CN1189176C | 2005-02-16 | |||
| US20040020277A1 | 2004-02-05 | |||
| CN1809364A | 2006-07-26 |
Other References:
KITAGAWA, I. ET AL.: "Saponin and Sapogenol. XXXV. Chemical constituents of Astragali Radix, the root of Astragalus membranaceus Bunge. (2). Astragalosides I, II, and IV, acetylastragaloside I and isoastragalosides I and II.", CHEM. PHARM. BULL., vol. 31, no. 2, 1983, pages 698 - 708, XP008132216
See also references of EP 2199402A4
ISAO KITAGAWA ET AL., CHEM. PHARM. BULL., vol. 31, no. 2, 1983, pages 698 - 708
See also references of EP 2199402A4
ISAO KITAGAWA ET AL., CHEM. PHARM. BULL., vol. 31, no. 2, 1983, pages 698 - 708
Attorney, Agent or Firm:
PANAWELL & PARTNERS, LLC (18th Floor Tower 2,Xihuan Plaza, 1 Xizhimenwai Street, Xicheng District, Beijing 4, CN)
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