Title:
Β-CYCLODEXTRIN-BASED STAR POLYMER AND PREPARATION METHOD, AND SINGLE-MOLECULE MICELLE INTEGRATED DIAGNOSIS AND TREATMENT SYSTEM THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/173846
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of biological medical high-molecular polymer materials, and discloses a β-cyclodextrin-based star polymer and a preparation method therefor, and a single-molecule micelle integrated diagnosis and treatment system based on the star polymer and use thereof. The polymer has a structure shown in formula (I), wherein x = 4-15, y = 3-20, and z = 10-30. The proportion of various blocks of the polymer can be easily adjusted, and a mono-dispersed single-molecule micelle having a stable structure can be prepared. Also provided are gold nanoparticles having a small particle size and good stability prepared in situ based on the above-mentioned polymer single-molecule micelle system. Also provided is a preparation technology based on the above-mentioned polymer single-molecule micelle system, which can be efficiently loaded with both the gold nanoparticles and a hydrophobic drug, realize a combination of tumour imaging diagnosis and tumour chemotherapy, improve cancer treatment efficiency, and provide value to the integrated diagnosis and treatment system.
Inventors:
ZHANG LIJUAN (CN)
LIN WENJING (CN)
YAO NA (CN)
ZHANG XIAOFANG (CN)
LIN WENJING (CN)
YAO NA (CN)
ZHANG XIAOFANG (CN)
Application Number:
PCT/CN2016/109907
Publication Date:
October 12, 2017
Filing Date:
December 14, 2016
Export Citation:
Assignee:
UNIV SOUTH CHINA TECH (CN)
International Classes:
C08G63/08; A61K9/107; A61K33/242; A61K47/34; A61K47/40; A61K49/04; C08B37/16; C08F220/28; C08F220/34; C08F293/00
Foreign References:
| CN105778021A | 2016-07-20 | |||
| CN105017445A | 2015-11-04 | |||
| CN102702454A | 2012-10-03 | |||
| CN102702453A | 2012-10-03 | |||
| TW200621268A | 2006-07-01 | |||
| US20040170595A1 | 2004-09-02 | |||
| CN103396521A | 2013-11-20 |
Other References:
NA YAO ET AL.: "Amphiphilic beta -cyclodextrin based star-like block copolymer unimolecular micelles for facile in situ preparation of gold nanoparticles", JOURNAL OF POLYMER SCIENCE , PART A: POLYMER CHEMISTRY, vol. 54, 10 January 2016 (2016-01-10), pages 187 - 196, XP055602388
LAURA M.THOMA ET AL.: "Cationic Methacrylate Polymers as Topical Antimicrobial Agents against Staphylococcus aureus Nasal Colonization", BIOMACROMOLECULES, vol. 15, no. 8, 11 August 2014 (2014-08-11), pages 2933 - 2943, XP055602391
CAIHONG ZHU ET AL.: "Cationic methacrylate copolymers containing primary and tertiary amino side groups: controlled synthesis via RAFT polymerization, DNA condensation, and in vitro gene transfection", JOURNAL OF POLYMER SCIENCE , PART A: POLYMER CHEMISTRY, vol. 48, no. 13, 1 July 2010 (2010-07-01), pages 2869 - 2877, XP055602394
LAURA M.THOMA ET AL.: "Cationic Methacrylate Polymers as Topical Antimicrobial Agents against Staphylococcus aureus Nasal Colonization", BIOMACROMOLECULES, vol. 15, no. 8, 11 August 2014 (2014-08-11), pages 2933 - 2943, XP055602391
CAIHONG ZHU ET AL.: "Cationic methacrylate copolymers containing primary and tertiary amino side groups: controlled synthesis via RAFT polymerization, DNA condensation, and in vitro gene transfection", JOURNAL OF POLYMER SCIENCE , PART A: POLYMER CHEMISTRY, vol. 48, no. 13, 1 July 2010 (2010-07-01), pages 2869 - 2877, XP055602394
Attorney, Agent or Firm:
GUANGZHOU HUAXUE INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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