Title:
CYCLODEXTRIN COMPLEXES
Document Type and Number:
WIPO Patent Application WO2003033025
Kind Code:
A3
Abstract:
The invention provides a number of methods for enhancing the aqueous solubility of an active ingredient which is insoluble or sparingly soluble in water. In one preferred embodiment, solubilization of the active ingredient is enhanced by combining it with beta-cyclodextrin in an aqueous complexation medium comprising beta-cyclodextrin and a negatively- or positively-charged compound which forms an inclusion or non-inclusion complex with beta-cyclodextrin and its inclusion complexes.
Inventors:
LOFTSSON THORSTEINN
Application Number:
PCT/IS2002/000018
Publication Date:
March 04, 2004
Filing Date:
October 17, 2002
Export Citation:
Assignee:
DECODE GENETICS EHF (IS)
International Classes:
A61K31/724; A61K45/06; A61K47/40; A61K47/48; A61K47/10; A61K47/12; A61K47/38; (IPC1-7): A61K47/40
Foreign References:
| EP0579435A1 | 1994-01-19 |
Other References:
REDENTI ENRICO ET AL: "Drug/cyclodextrin/hydroxy acid multicomponent systems. Properties and pharmaceutical applications.", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 89, no. 1, January 2000 (2000-01-01), pages 1 - 8, XP002228178, ISSN: 0022-3549
PATENT ABSTRACTS OF JAPAN vol. 011, no. 268 (C - 444) 29 August 1987 (1987-08-29)
T. LOFTSSON ET AL: "The Influence of Water-Soluble Polymers and pH on Hydroxypropyl-beta-Cyclodextrin Complexation of Drugs", DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 22, no. 5, 1996, pages 401 - 405, XP002228179
LOFTSSON THORSTEINN ET AL: "Cyclodextrin complexation of NSAIDS: Physicochemical characteristics.", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 1, no. 2, 1993, pages 95 - 101, XP002228180, ISSN: 0928-0987
LOFTSSON THORSTEINN ET AL: "The effect of polyvinylpyrrolidone and hydroxypropyl methylcellulose of HP-beta-CD complexation of hydrocortisone and its permeability through hairless mouse skin.", 1994, EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 2, NR. 4, PAGE(S) 297-301, ISSN: 0928-0987, XP002228181
PATENT ABSTRACTS OF JAPAN vol. 011, no. 268 (C - 444) 29 August 1987 (1987-08-29)
T. LOFTSSON ET AL: "The Influence of Water-Soluble Polymers and pH on Hydroxypropyl-beta-Cyclodextrin Complexation of Drugs", DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 22, no. 5, 1996, pages 401 - 405, XP002228179
LOFTSSON THORSTEINN ET AL: "Cyclodextrin complexation of NSAIDS: Physicochemical characteristics.", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 1, no. 2, 1993, pages 95 - 101, XP002228180, ISSN: 0928-0987
LOFTSSON THORSTEINN ET AL: "The effect of polyvinylpyrrolidone and hydroxypropyl methylcellulose of HP-beta-CD complexation of hydrocortisone and its permeability through hairless mouse skin.", 1994, EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 2, NR. 4, PAGE(S) 297-301, ISSN: 0928-0987, XP002228181
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