Title:
CYCLOHEPTA[B]PYRIDINE COMPOUNDS, PREPARATION METHOD AND USAGE THEREOF AS WELL AS PHARMACEUTICAL COMPOSITIONS CONTAINING THE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2008/125008
Kind Code:
A1
Abstract:
The invention provides a cyclohepta[b]pyridine compounddescribed as
formula I and pharmaceutically acceptable salts thereof. The invention also provides
the method for preparation of these cyclohepta[b]pyridine compounds as well
as the use of these cyclohepta[b]pyridine compounds and compositions thereof
in preparing medicines for treatment and prophylaxis of Alzheimer's disease,
children mental retardation, amnesia and other cardiovascular and cerebrovascular
diseases. The compounds of present invention can be used as agonist or/and inhibitor
of α, β, γ-secretase. The compounds prevent production
of amyloid by actuation or inhibition activity of enzymes and can effectually
treat and/or prevent Alzheimer's disease, children mental retardation,
amnesia and other cardiovascular and cerebrovascular diseases.
Inventors:
JIANG HUALIANG (CN)
SHEN XU (CN)
LIU HONG (CN)
YAO ZHIYI (CN)
LI CHENJING (CN)
ZHOU YU (CN)
CHEN KAIXIAN (CN)
SHEN XU (CN)
LIU HONG (CN)
YAO ZHIYI (CN)
LI CHENJING (CN)
ZHOU YU (CN)
CHEN KAIXIAN (CN)
Application Number:
PCT/CN2008/000722
Publication Date:
October 23, 2008
Filing Date:
April 09, 2008
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA (CN)
JIANG HUALIANG (CN)
SHEN XU (CN)
LIU HONG (CN)
YAO ZHIYI (CN)
LI CHENJING (CN)
ZHOU YU (CN)
CHEN KAIXIAN (CN)
JIANG HUALIANG (CN)
SHEN XU (CN)
LIU HONG (CN)
YAO ZHIYI (CN)
LI CHENJING (CN)
ZHOU YU (CN)
CHEN KAIXIAN (CN)
International Classes:
C07D221/04; A61K31/438; A61P25/28
Domestic Patent References:
| WO1999067220A1 | 1999-12-29 | |||
| WO2001060826A2 | 2001-08-23 |
Foreign References:
| CN1242007A | 2000-01-19 |
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (Block B Kingsound International Center, 116 Zizhuyuan Road, Haidian, Beijing 7, CN)
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