Title:
CYCLOHEXANE DERIVATIVE OR STEREOISOMER OR SALT THEREOF, AND PREPARATION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/045599
Kind Code:
A1
Abstract:
Provided are a cyclohexane derivative as shown by formula IB or a stereoisomer or a salt thereof, and the preparation and use thereof. The cyclohexane derivative has a high affinity for D3 receptors and 5-hydroxytryptamine, has a lower affinity for D2 receptors, shows a high selectivity for D3/D2 receptors, and can be used as a therapeutic drug against neuropsychiatric diseases; and the preparation method thereof is simple and easy.
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Inventors:
HUANG YUE (CN)
ZHENG FEI (CN)
ZHENG FEI (CN)
Application Number:
PCT/CN2016/098953
Publication Date:
March 23, 2017
Filing Date:
September 14, 2016
Export Citation:
Assignee:
ZHEJIANG JINGXIN PHARMACEUTICAL CO LTD (CN)
SHANGHAI JINGXIN BIOMEDICAL CO LTD (CN)
SHANGYU JINGXIN PHARMACEUTICAL CO LTD (CN)
SHANGHAI JINGXIN BIOMEDICAL CO LTD (CN)
SHANGYU JINGXIN PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D333/54; A61K31/4523; A61K31/497; C07D333/66; C07D333/72; C07D413/04; C07D413/12; A61P25/18; A61P25/22; A61P25/24; A61P25/28
Foreign References:
| CN103130737A | 2013-06-05 | |||
| CN101511805A | 2009-08-19 | |||
| CN102159557A | 2011-08-17 | |||
| CN102164914A | 2011-08-24 | |||
| CN101778844A | 2010-07-14 | |||
| CN102164927A | 2011-08-24 | |||
| CN104140421A | 2014-11-12 | |||
| CN101107236A | 2008-01-16 | |||
| CN102958936A | 2013-03-06 |
Other References:
See also references of EP 3351540A4
Attorney, Agent or Firm:
SHANGHAI XIN TIAN PATENT AGENCY CO., LTD. (CN)
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