Title:
CYCLOHEXANE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2007/063839
Kind Code:
A1
Abstract:
Disclosed is a cyclohexane derivative represented by the formula (I), which can
bind specifically to an NR1/NR2B receptor and therefore can be used as an analgesic agent
(a therapeutic agent for pain): (I) wherein A1 represents a (substituted) aromatic
cyclic group having -NH- in the ring or the like; A2 represents a (substituted)
phenyl or the like; R1, R2a, R2b and R2c
independently represent a hydrogen, a hydroxy or the like; m represents 0 or 1;
X represents -CONH(CR3R4)n-, -NHCO(CR3R4)n-, -A3-(CR3R4)n-
or the like; R3 and R4 independently represent a hydrogen
or a (substituted) lower alkyl; n is an integer of 0 to 4; A3 represents
a phenylene or the like; and Y represents a single bond, a lower alkylene or the
like.
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Inventors:
MASUI MORIYASU (JP)
MIKAMIYAMA HIDENORI (JP)
TSUNO NAOKI (JP)
MATSUMURA AKIRA (JP)
KAI HIROYUKI (JP)
ANAN KOUSUKE (JP)
MIKAMIYAMA HIDENORI (JP)
TSUNO NAOKI (JP)
MATSUMURA AKIRA (JP)
KAI HIROYUKI (JP)
ANAN KOUSUKE (JP)
Application Number:
PCT/JP2006/323693
Publication Date:
June 07, 2007
Filing Date:
November 28, 2006
Export Citation:
Assignee:
SHIONOGI & CO (JP)
MASUI MORIYASU (JP)
MIKAMIYAMA HIDENORI (JP)
TSUNO NAOKI (JP)
MATSUMURA AKIRA (JP)
KAI HIROYUKI (JP)
ANAN KOUSUKE (JP)
MASUI MORIYASU (JP)
MIKAMIYAMA HIDENORI (JP)
TSUNO NAOKI (JP)
MATSUMURA AKIRA (JP)
KAI HIROYUKI (JP)
ANAN KOUSUKE (JP)
International Classes:
C07D207/34; A61K31/40; A61K31/415; A61K31/4164; A61K31/4184; A61K31/423; A61K31/4409; A61K31/4412; A61K31/444; A61K31/455; A61P9/00; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P25/32; A61P43/00; C07D213/64; C07D213/75; C07D213/82; C07D231/14; C07D233/90; C07D235/26; C07D263/58
Domestic Patent References:
| WO2005080317A2 | 2005-09-01 | |||
| WO2004047755A2 | 2004-06-10 | |||
| WO1998004534A1 | 1998-02-05 | |||
| WO2005019221A1 | 2005-03-03 | |||
| WO2004054579A1 | 2004-07-01 |
Foreign References:
| JP2003513080A | 2003-04-08 | |||
| JP2004512324A | 2004-04-22 | |||
| JP2002326988A | 2002-11-15 | |||
| JP2005518365A | 2005-06-23 | |||
| JP2004509154A | 2004-03-25 | |||
| JP2003535851A | 2003-12-02 |
Attorney, Agent or Firm:
TAKAYAMA, Hirotsugu et al. (Intellectual Property Department, 12-4, Sagisu 5-chome, Fukushima-k, Osaka-shi Osaka 02, JP)
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