CYCLOOCTANONE DERIVATIVE AND CYCLODECANONE DERIVATIVE, AND USE THEREOF

Title:

CYCLOOCTANONE DERIVATIVE AND CYCLODECANONE DERIVATIVE, AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2002/081420

Kind Code:

A1

Abstract:

A compound which has cytokine production inhibitory activity and is useful for the treatment of diseases in which cytokine participates. The compound is represented by the following general formula (I) [wherein A represents an optionally substituted cyclic compound group; the partial structure -D---E- represents -CH�2?CH�2?- or -CH=CH-; W represents -CH�2?-, -CH�2?CH�2?-, -CH=CH-, or -CH=; the partial structure >X---Y- represents >CH-(CH�2?)�n?-, >C=CH-, >CH-CH�2?-CH(OH)-, >CH-CH�2?-C(=O)-, >CH-O-, or >CH-O-CO-, provided that when W is -CH=, then X---Y- represents C-(CH�2?)�p?-; Z represents a divalent aliphatic hydrocarbon group; R?1� and R?2� are the same or different and each represents hydrogen, hydroxy, alkoxy, or alkoxyalkoxy; and m is 0 or 1]. (I)

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Inventors:

EGUCHI YOSHIHITO (JP)
CHIBA KEN-ICHI (JP)
GOTO MASAKI (JP)
OBAISHI HIROSHI (JP)
KUBOI YOSHIKAZU (JP)

Application Number:

PCT/JP2002/003258

Publication Date:

October 17, 2002

Filing Date:

April 01, 2002

Export Citation:

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Assignee:

EISAI CO LTD (JP)
EGUCHI YOSHIHITO (JP)
CHIBA KEN-ICHI (JP)
GOTO MASAKI (JP)
OBAISHI HIROSHI (JP)
KUBOI YOSHIKAZU (JP)

International Classes:

A61K31/12; A61K31/235; A61K31/24; A61K31/4402; A61P1/04; A61P1/16; A61P3/10; A61P13/12; A61P17/00; A61P19/02; A61P27/02; A61P29/00; A61P43/00; C07C49/657; C07C49/747; C07C49/753; C07C205/57; C07D207/12; C07D401/04; C07D453/02; (IPC1-7): C07C49/413; C07C49/503; C07C49/517; C07C49/717; C07C49/747; C07C49/753; C07C49/84; C07C69/76; C07C205/60; C07D213/16; A61K31/12; A61K31/235; A61K31/24; A61K31/4402; A61P1/04; A61P1/16; A61P3/10; A61P13/12; A61P17/00; A61P19/02; A61P27/02; A61P29/00; A61P43/00

Domestic Patent References:

WO2000055139A2

2000-09-21

Foreign References:

JPS6281343A	1987-04-14
EP0934940A1	1999-08-11
EP1008346A1	2000-06-14
EP1018514A1	2000-07-12

Other References:

PETER G. JONES, GEORGE M. SHELDRICK: "The crystal structures of 1-(3',5'-dinitrobenzoyloxy)-bicyclo(3.3.1)-9-oxanonane and 5-(3',5'-dinitrobenzoyloxy)-cyclooctanone", ZEITSCHRIIFT FUER KRISTALLOGRAPHIE, vol. 163, 1983, pages 75 - 84, XP002953405
See also references of EP 1375465A4

Attorney, Agent or Firm:

Inami, Minoru (INABA & INAMI Hanabishi Imas Hirakawacho Building, 4th Floor, 3-11, Hirakawacho 2-chom, Chiyoda-ku Tokyo, JP)

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