Title:
CYCLOOCTIN DERIVATIVE AND SALT THEREOF, ENRICHMENT METHOD AND DETECTION METHOD OF TARGET MOLECULES USING THIS, AND ENRICHMENT OR DETECTION KIT
Document Type and Number:
WIPO Patent Application WO/2022/092301
Kind Code:
A1
Abstract:
This cyclooctin derivative and salt thereof are represented in formula (1). (In the formula, X represents -CHR6-, -NR7- or -O-; L represents a linker group; in the case of not being a linker group, R1-R7 independently represent a hydrogen atom, a C1-C3 alkyl group, a halogen, a hydroxy group, and oxo group, a cyano group or an amino group; in the C1-C3 alkyl groups, one or more hydrogen atoms may be substituted by a halogen, a hydroxy group, a cyano group or an amino group; in L, two groups selected from R1-R6, or two groups selected from R1-R5 and R7 may be substituted to form a ring structure). Further, an enrichment method and detection method of target molecules using the cyclooctin derivative or a salt thereof, and an enrichment or detection kit are provided.
Inventors:
HORIUCHI YAYOI (JP)
SHIN JIHYE (JP)
RYO AKIHIDE (JP)
KOBASHI TATSUHIRO (JP)
SHIN JIHYE (JP)
RYO AKIHIDE (JP)
KOBASHI TATSUHIRO (JP)
Application Number:
PCT/JP2021/040162
Publication Date:
May 05, 2022
Filing Date:
October 29, 2021
Export Citation:
Assignee:
NARD INSTITUTE LTD (JP)
International Classes:
C07K1/13; C07F9/09; C07F9/553; C07K1/14; G01N27/62; G01N33/48
Foreign References:
| JP2019532012A | 2019-11-07 |
Other References:
KLEINPENNING FLEUR, STEIGENBERGER BARBARA, WU WEI, HECK ALBERT J. R.: "Fishing for newly synthesized proteins with phosphonate-handles", NATURE COMMUNICATIONS, vol. 11, no. 1, 1 December 2020 (2020-12-01), pages 1 - 10, XP055926636, DOI: 10.1038/s41467-020-17010-0
"Protein Modifications in Pathogenic Dysregulation of Signaling", 14 September 2015, SPRINGER, Tokyo, ISBN: 978-4-431-55560-5, article EIJI KINOSHITA, EMIKO KINOSHITA-KIKUTA, TOHRU KOIKE: "Phos-tag-Based Affinity Chromatography Techniques for Enrichment of the Phosphoproteome", pages: 17 - 30, XP009536211, DOI: 10.1007/978-4-431-55561-2_2
EIJI KINOSHITA: "Development and Application of Phos-tag Technology for Phosphoproteomics", PROTEOME LETTERS, vol. 4, no. 2, 1 January 2019 (2019-01-01), pages 49 - 60, XP055926651, ISSN: 2432-2776, DOI: 10.14889/jpros.4.2_49
KINOSHITA-KIKUTA EMIKO, YAMADA ATSUSHI, INOUE CHIKA, KINOSHITA EIJI, KOIKE TOHRU: "A novel phosphate-affinity bead with immobilized Phos-tag for separation and enrichment of phosphopeptides and phosphoproteins", JOURNAL OF INTEGRATED OMICS, vol. 1, no. 1, 1 February 2011 (2011-02-01), pages 157 - 169, XP055926658, DOI: 10.5584/jiomics.v1i1.46
IVANA NIKIĆ; EDWARD A LEMKE: "Genetic code expansion enabled site-specific dual-color protein labeling: superresolution microscopy and beyond", CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 28, 1 October 2015 (2015-10-01), GB , pages 164 - 173, XP055342581, ISSN: 1367-5931, DOI: 10.1016/j.cbpa.2015.07.021
"Protein Modifications in Pathogenic Dysregulation of Signaling", 14 September 2015, SPRINGER, Tokyo, ISBN: 978-4-431-55560-5, article EIJI KINOSHITA, EMIKO KINOSHITA-KIKUTA, TOHRU KOIKE: "Phos-tag-Based Affinity Chromatography Techniques for Enrichment of the Phosphoproteome", pages: 17 - 30, XP009536211, DOI: 10.1007/978-4-431-55561-2_2
EIJI KINOSHITA: "Development and Application of Phos-tag Technology for Phosphoproteomics", PROTEOME LETTERS, vol. 4, no. 2, 1 January 2019 (2019-01-01), pages 49 - 60, XP055926651, ISSN: 2432-2776, DOI: 10.14889/jpros.4.2_49
KINOSHITA-KIKUTA EMIKO, YAMADA ATSUSHI, INOUE CHIKA, KINOSHITA EIJI, KOIKE TOHRU: "A novel phosphate-affinity bead with immobilized Phos-tag for separation and enrichment of phosphopeptides and phosphoproteins", JOURNAL OF INTEGRATED OMICS, vol. 1, no. 1, 1 February 2011 (2011-02-01), pages 157 - 169, XP055926658, DOI: 10.5584/jiomics.v1i1.46
IVANA NIKIĆ; EDWARD A LEMKE: "Genetic code expansion enabled site-specific dual-color protein labeling: superresolution microscopy and beyond", CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 28, 1 October 2015 (2015-10-01), GB , pages 164 - 173, XP055342581, ISSN: 1367-5931, DOI: 10.1016/j.cbpa.2015.07.021
Attorney, Agent or Firm:
HAYAKAWA Yuzi et al. (JP)
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